Lee C M, Wong C C
Department of Biochemistry, Faculty of Medicine, Chinese University of Hong Kong, Shatin.
Neurosci Lett. 1989 May 22;100(1-3):281-6. doi: 10.1016/0304-3940(89)90699-x.
A significant increase in the size and weight of the urinary bladder was observed 2 weeks after streptozotocin treatment and 2 months after neonatal capsaicin treatment. Both treatments induced a significant increase in the level of [3H]quinuclidinyl benzilate binding to muscarinic cholinergic receptors in the urinary bladder membranes. However, contractile responses of urinary bladder muscle strips to carbachol (0.3-20 microM) were not significantly affected by either treatment. On the other hand, neonatal capsaicin treatment, but not streptozotocin treatment, significantly enhanced contractile responses of bladder strips to electric field stimulation.
链脲佐菌素治疗2周后以及新生鼠辣椒素治疗2个月后，观察到膀胱的大小和重量显著增加。两种治疗均导致膀胱膜中与毒蕈碱胆碱能受体结合的[3H]喹核醇基苯甲酸酯水平显著升高。然而，两种治疗对膀胱肌条对卡巴胆碱（0.3 - 20 microM）的收缩反应均无显著影响。另一方面，新生鼠辣椒素治疗而非链脲佐菌素治疗显著增强了膀胱条对电场刺激的收缩反应。
