Davis T M, Proby C, Strong J A, Thompson G R, Massey H, Scott R, Bloom S R
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Diabet Med. 1989 Jul;6(5):400-5. doi: 10.1111/j.1464-5491.1989.tb01193.x.
Enprostil, a dehydro-prostaglandin E2 analogue, has been tested as treatment for peptic ulcer. Its effect on blood glucose and lipid metabolism in Type 2 diabetes was assessed in a randomized, double-blind trial. Fifteen patients on sulphonylurea therapy received, in addition, enprostil 35 micrograms or placebo thrice daily for two weeks, with a 2-week wash-out before crossover. Data from 12 patients were analysed. After a 530 Cal test breakfast at the end of active treatment, plasma glucose rose from a fasting concentration similar to that after the last placebo dose (10.5 +/- 0.8 (+/- SE) and 10.6 +/- 1.1 mmol l-1 respectively) to 1, 2 and 3 h concentrations which were 1.5 to 2.1 mmol l-1 lower than on placebo (2 h concentration 14.6 +/- 0.9 vs 16.4 +/- 1.3 mmol l-1, p less than 0.05). Serum fructosamine concentrations at the end of active treatment and placebo were 3.66 +/- 0.22 and 3.78 +/- 0.24 respectively (p = 0.051). No changes in fasting or post-prandial insulin concentrations were observed. After 2 weeks of enprostil, fasting serum triglyceride (1.76 +/- 0.18 mmol l-1) and total cholesterol (6.27 +/- 0.29 mmol l-1) concentrations were lower than after placebo (2.14 +/- 0.25 and 7.35 +/- 0.46 mmol l-1, p = 0.031 and p = 0.002, respectively), the latter effect being primarily due to reduced LDL-cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)
恩前列素是一种脱氢前列腺素E2类似物，已被作为消化性溃疡的治疗药物进行测试。在一项随机双盲试验中评估了其对2型糖尿病患者血糖和脂质代谢的影响。15名接受磺脲类药物治疗的患者，另外每日三次服用35微克恩前列素或安慰剂，持续两周，交叉前有两周的洗脱期。分析了12名患者的数据。在积极治疗结束时进行530卡路里的测试早餐后，血浆葡萄糖从与最后一剂安慰剂后相似的空腹浓度（分别为10.5±0.8（±标准误）和10.6±1.1毫摩尔/升）升至1小时、2小时和3小时浓度，比服用安慰剂时低1.5至2.1毫摩尔/升（2小时浓度为14.6±0.9与16.4±1.3毫摩尔/升，p<0.05）。积极治疗结束时和安慰剂时的血清果糖胺浓度分别为3.66±0.22和3.78±0.24（p = 0.051）。未观察到空腹或餐后胰岛素浓度的变化。服用恩前列素2周后，空腹血清甘油三酯（1.76±0.18毫摩尔/升）和总胆固醇（6.27±0.29毫摩尔/升）浓度低于服用安慰剂后（分别为2.14±0.25和7.35±0.46毫摩尔/升，p = 0.031和p = 0.002），后一种效应主要是由于低密度脂蛋白胆固醇降低。（摘要截断于250字）
