An analysis of Trichinella pseudospiralis excretions and study of their effect on striated muscles of mouse.

The causes of changes observed after infection of muscles with Trichinella pseudospiralis larvae were studied. The changes are not only regressive, but also proliferative (activation and mitosis of satellite cells and formation of new myotubes). By means of high-performance liquid chromatography (HPLC) and an original method it was found that T. pseudospiralis larvae excrete into their environment among others a great amount of n-butylamine. A direct application of n-butylamine into the gluteal muscle of mouse supported the assumption that this amine is one of the factors causing the changes in muscles induced by T. pseudospiralis infection. The application of n-butylamine into the muscle resulted in regressive and regenerative changes similar to that observed in case of T. pseudospiralis infection.