Zinberg E M, Choo D I, Zotter L A
Department of Orthopaedic Surgery, SUNY Health Science Center, Syracuse.
Microsurgery. 1989;10(2):103-7; discussion 108-9. doi: 10.1002/micr.1920100205.
The effect of five different irrigating solutions on patency of four different types of microvascular anastomoses was studied. The solutions used were lactated Ringer's without heparin and four lactated Ringer's solutions with varying concentrations of heparin ranging from 10,000 units/liter to 100,000 units/liter. These were tested on four different anastomotic models in the rat: 1) end-to-end femoral arterial anastomosis; 2) end-to-side arterial bypass graft; 3) end-to-end venous anastomosis; and 4) end-to-side venous bypass graft. There were statistically significant differences in patency rates among the solutions only in the end-to-end venous anastomosis group. In these, significantly higher patency was achieved with heparinized lactated Ringer's solution at 20,000 units/liter. The use of higher concentrations of heparin in these solutions resulted in decreasing patency rates and appears to be contraindicated.
研究了五种不同冲洗液对四种不同类型微血管吻合通畅性的影响。所用的冲洗液为不含肝素的乳酸林格氏液以及四种不同浓度肝素（范围从10,000单位/升至100,000单位/升）的乳酸林格氏液。这些冲洗液在大鼠的四种不同吻合模型上进行了测试：1）股动脉端端吻合；2）动脉端侧旁路移植；3）静脉端端吻合；4）静脉端侧旁路移植。仅在静脉端端吻合组中，各冲洗液的通畅率存在统计学显著差异。在这些模型中，使用20,000单位/升肝素化乳酸林格氏液可显著提高通畅率。在这些冲洗液中使用更高浓度的肝素会导致通畅率降低，似乎是禁忌的。
