Chan Pei-Ying S, von Leupoldt Andreas, Liu Chia-Yih, Hsu Shih-Chieh
Department of Occupational Therapy, College of Medicine, and Healthy Ageing Research Center, Chang Gung University, 259 Wen-Hwa 1st Road, Taoyuan 333, Taiwan.
Research group on Health Psychology, University of Leuven, Tiensestraat 102, B-3000 Leuven, Belgium; Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Respir Physiol Neurobiol. 2014 Dec 1;204:36-40. doi: 10.1016/j.resp.2014.09.009. Epub 2014 Oct 2.
There has been evidence for the effect of anxiety on the neural processing of respiratory sensation using the respiratory-related evoked potentials (RREP) elicited by inspiratory occlusions. This study tested the RREP elicited by inspiratory occlusions in a group of outpatients with generalized anxiety disorder (GAD) and a group of healthy controls. We hypothesized that the RREP P3 peak would be modulated in the GAD patients. A RREP oddball paradigm of 150-ms inspiratory occlusion protocol was used in 15 GAD patients and 11 healthy adults with normal lung functions. The RREP was recorded with a 40-channel electroencephalography (EEG) system. A minimum of 100 occlusions was collected for data analysis. We found that the averaged P3 latency of the GAD patients was significantly longer than the P3 latency of the healthy controls. In addition, the GAD group showed significantly reduced P3 amplitudes compared to the control group. No group differences in latency and amplitudes were found for earlier RREP components. These results demonstrated that a delayed and reduced attention peak (P3) is present in patients with GAD. This suggests that GAD as a disease state modulates the higher order processing of respiratory perception.
已有证据表明，焦虑会通过吸气阻断诱发的呼吸相关诱发电位（RREP）对呼吸感觉的神经处理产生影响。本研究测试了一组广泛性焦虑障碍（GAD）门诊患者和一组健康对照者在吸气阻断时诱发的RREP。我们假设GAD患者的RREP P3波峰将受到调节。15名GAD患者和11名肺功能正常的健康成年人采用了150毫秒吸气阻断方案的RREP Oddball范式。使用40通道脑电图（EEG）系统记录RREP。至少收集100次阻断用于数据分析。我们发现，GAD患者的平均P3潜伏期明显长于健康对照者的P3潜伏期。此外，与对照组相比，GAD组的P3波幅明显降低。早期RREP成分在潜伏期和波幅上未发现组间差异。这些结果表明，GAD患者存在注意力峰值（P3）延迟和降低的情况。这表明GAD作为一种疾病状态会调节呼吸感知的高级处理过程。
