Knopman David S, Petersen Ronald C
Department of Neurology, Division of Behavioral Neurology, Mayo Clinic, Rochester, MN.
Department of Neurology, Division of Behavioral Neurology, Mayo Clinic, Rochester, MN.
Mayo Clin Proc. 2014 Oct;89(10):1452-9. doi: 10.1016/j.mayocp.2014.06.019.
Mild cognitive impairment and mild dementia are common problems in the elderly. Primary care physicians are the first point of contact for most patients with these disorders and should be familiar with their diagnosis, prognosis, and management. Both mild cognitive impairment and mild dementia are characterized by objective evidence of cognitive impairment. The main distinctions between mild cognitive impairment and mild dementia are that in the latter, more than one cognitive domain is invariably involved and substantial interference with daily life is evident. The diagnosis of mild cognitive impairment and mild dementia is based mainly on the history and cognitive examination. The prognosis for mild cognitive impairment and mild dementia is an important motivation for diagnosis because in both, there is a heightened risk for further cognitive decline. The etiology of mild cognitive impairment and mild dementia can often be established through the clinical examination, although imaging and other laboratory tests may also contribute. Although Alzheimer disease is the most common cause of both, cerebrovascular disease and Lewy body disease make important contributions. Pharmacological treatments are of modest value in mild dementia due to Alzheimer disease, and there are no approved pharmacological treatments for mild cognitive impairment of any etiology. Nonetheless, new-onset cognitive impairment is a worrisome symptom to patients and families that demands answers and advice. If a patient is having difficulties managing medications, finances, or transportation independently, diagnosis and intervention are necessary to ensure the health and safety of the patient.
轻度认知障碍和轻度痴呆是老年人常见的问题。初级保健医生是大多数患有这些疾病的患者的首要接触点,应该熟悉它们的诊断、预后和管理。轻度认知障碍和轻度痴呆都以认知障碍的客观证据为特征。轻度认知障碍和轻度痴呆之间的主要区别在于,在后者中,总是涉及不止一个认知领域,并且对日常生活有明显的实质性干扰。轻度认知障碍和轻度痴呆的诊断主要基于病史和认知检查。轻度认知障碍和轻度痴呆的预后是诊断的一个重要动机,因为在这两种情况下,进一步认知衰退的风险都增加。轻度认知障碍和轻度痴呆的病因通常可以通过临床检查确定,尽管影像学和其他实验室检查也可能有帮助。虽然阿尔茨海默病是两者最常见的病因,但脑血管疾病和路易体病也有重要影响。对于由阿尔茨海默病引起的轻度痴呆,药物治疗价值有限,对于任何病因的轻度认知障碍都没有批准的药物治疗方法。尽管如此,新发认知障碍对患者和家属来说是一个令人担忧的症状,需要得到答案和建议。如果患者在独立管理药物、财务或交通方面有困难,诊断和干预对于确保患者的健康和安全是必要的。