Xu Mafei, Qin Jun, Tsai Sophia Y, Tsai Ming-jer
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
1] Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA [2] Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, Shanghai 200025, China.
Acta Pharmacol Sin. 2015 Jan;36(1):32-6. doi: 10.1038/aps.2014.86. Epub 2014 Oct 6.
The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be identified. Since the discovery of COUP-TFs in 1986, extensive studies have demonstrated their crucial functions in a variety of developmental processes, such as organogenesis, angiogenesis, and metabolic homeostasis. Recently, emerging evidence has highlighted that COUP-TFs, specifically COUP-TFII, play important roles in tumorigenesis. In this review, we will discuss the critical functions of COUP-TFII in the development of the tumor microenvironment, the progression of various cancers, and its underlying mechanisms.
鸡卵清蛋白上游启动子转录因子（COUP-TFs）是核受体超家族的成员，由两种高度同源的亚型组成，即COUP-TFI（EAR-3，NR2F1）和COUP-TFII（ARP-1，NR2F2）。它们被称为孤儿受体，因为COUP-TF的配体尚未被鉴定出来。自1986年发现COUP-TFs以来，广泛的研究表明它们在多种发育过程中发挥着关键作用，如器官发生、血管生成和代谢稳态。最近，新出现的证据突出表明，COUP-TFs，特别是COUP-TFII，在肿瘤发生中发挥重要作用。在这篇综述中，我们将讨论COUP-TFII在肿瘤微环境发展、各种癌症进展及其潜在机制中的关键作用。
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