皮摩尔浓度的重组人脂皮质素I对正常和银屑病表皮磷脂酶A2的抑制作用。
Inhibition of normal and psoriatic epidermal phospholipase A2 by picomolar concentrations of recombinant human lipocortin I.
作者信息
Cartwright P H, Ilderton E, Sowden J M, Yardley H J
机构信息
Department of Dermatology, North Staffordshire Hospital Centre, Stoke-on-Trent, U.K.
出版信息
Br J Dermatol. 1989 Aug;121(2):155-60. doi: 10.1111/j.1365-2133.1989.tb01794.x.
Abstract
Normal human and psoriatic epidermal phospholipase A2 (PLA2) was inhibited by human recombinant lipocortin I when the substrate was present in a several million-fold molar excess. Inhibition was not total, even at relatively high concentrations of lipocortin I. It is therefore suggested that human epidermis contains two species of PLA2: one that is controlled by lipocortin I and one that is not.
摘要
当底物存在数百万倍的摩尔过量时，人重组脂皮质蛋白I可抑制正常人及银屑病患者表皮的磷脂酶A2（PLA2）。即使在相对高浓度的脂皮质蛋白I存在时，抑制也不完全。因此，提示人表皮含有两种PLA2：一种受脂皮质蛋白I调控，另一种不受其调控。
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