Xie Kun-Lin, Zhang Yan-Ge, Liu Jun, Zeng Yong, Wu Hong
1. The Department of Liver Surgery & Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China;
2. The Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China;
Theranostics. 2014 Sep 19;4(12):1176-92. doi: 10.7150/thno.8715. eCollection 2014.
Hepatitis B virus (HBV) infection is a global problem and a major risk factor for hepatocellular carcinoma (HCC). microRNAs (miRNAs) comprise a group of small noncoding RNAs regulating gene expression at the posttranslational level, thereby participating in fundamental biological processes, including cell proliferation, differentiation, and apoptosis. In this review, we summarize the roles of miRNAs in HBV infection, the recently identified mechanism underlying dysregulation of miRNAs in HBV-associated HCC, and their association with hepatocarcinogenesis. Moreover, we discuss the recent advances in the use of circulating miRNAs in the early diagnosis of HCC as well as therapies based on these aberrantly expressed miRNAs.
乙型肝炎病毒（HBV）感染是一个全球性问题，也是肝细胞癌（HCC）的主要危险因素。微小RNA（miRNA）是一组小的非编码RNA，在翻译后水平调节基因表达，从而参与包括细胞增殖、分化和凋亡在内的基本生物学过程。在本综述中，我们总结了miRNA在HBV感染中的作用、最近发现的HBV相关HCC中miRNA失调的潜在机制及其与肝癌发生的关系。此外，我们还讨论了循环miRNA在HCC早期诊断中的应用以及基于这些异常表达miRNA的治疗方法的最新进展。
