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不可改变因素和并发症会影响机器人辅助部分肾切除术的住院时间。

Nonmodifiable factors and complications contribute to length of stay in robot-assisted partial nephrectomy.

作者信息

Larson Jeffrey A, Kaouk Jihad H, Stifelman Michael D, Rogers Craig G, Allaf Mohamad E, Potretzke Aaron, Marshall Susan, Zargar Homayoun, Ball Mark W, Bhayani Sam B

机构信息

1 Division of Urology, Washington University School of Medicine , Saint Louis, Missouri.

出版信息

J Endourol. 2015 Apr;29(4):422-9. doi: 10.1089/end.2014.0424. Epub 2014 Dec 30.

Abstract

INTRODUCTION/OBJECTIVE: Robotic-assisted partial nephrectomy (RPN) offers a mean length of stay (LOS) of 2 to 3 days. The purpose of this study is to determine the impact of modifiable and nonmodifiable risk factors on hospital LOS after RPN.

PATIENTS AND METHODS

We retrospectively reviewed our prospectively maintained database to identify all patients undergoing RPN for localized tumors at five US centers from 2007 to 2013. Patient and tumor characteristics were compared among hospital LOS groups. Associated factors were modeled using univariate and multivariate cumulative logistic regression to determine factors predictive of hospital LOS.

RESULTS

One thousand five hundred thirty-two patients were grouped into LOS 1 to 3 days (1298, 84.1%), LOS=4 days (133, 8.6%), and LOS >4 days (110, 7.2%). Patient demographics were similar between groups. Patients in the LOS=4 and LOS >4 day groups were more likely to have a higher Charlson comorbidity index score (mean 2.2, 3.1 and 3.8; p<0.001), higher nephrometry score (mean 7.1, 7.6, 7.8; p=0.0002), and larger tumors (mean 2.9, 3.6 and 3.5 cm; p<0.0001) than those in the LOS 1 to 3 day group. Significant differences in complication rates were observed when comparing LOS 1-3 (116, 8.9%), LOS=4 (40, 30%), and LOS >4 (59, 54%). According to the Clavien-Dindo classification of surgical complications, 11 grade 3 and 11 grade 4 complications occurred in patients with an LOS of 4 or more days (p<0.0001). Postoperative transfusion, deep vein thrombosis, pulmonary embolism, atrial fibrillation, dyspnea/atelectasis, ileus, and acute renal failure each significantly predicted a hospital LOS >4 days (p<0.001).

CONCLUSION

15.8% of patients undergoing RPN have an LOS of 4 days or more. Longer LOS was independently associated with higher Charlson index, nephrometry score (nonmodifiable factors), and perioperative complications (potentially modifiable). These data may be useful in perioperative counseling and payer precertification.

摘要

引言/目的:机器人辅助部分肾切除术(RPN)的平均住院时间为2至3天。本研究的目的是确定可改变和不可改变的风险因素对RPN术后住院时间的影响。

患者与方法

我们回顾性分析了前瞻性维护的数据库,以确定2007年至2013年在美国五个中心接受RPN治疗局限性肿瘤的所有患者。比较了不同住院时间组的患者和肿瘤特征。使用单因素和多因素累积逻辑回归对相关因素进行建模,以确定预测住院时间的因素。

结果

1532例患者被分为住院时间1至3天组(1298例,84.1%)、住院时间=4天组(133例,8.6%)和住院时间>4天组(110例,7.2%)。各组患者的人口统计学特征相似。住院时间=4天组和住院时间>4天组的患者比住院时间1至3天组的患者更有可能具有更高的Charlson合并症指数评分(平均2.2、3.1和3.8;p<0.001)、更高的肾计量评分(平均7.1、7.6、7.8;p=0.0002)以及更大的肿瘤(平均2.9、3.6和3.5 cm;p<0.0001)。比较住院时间1 - 3天组(116例,8.9%)、住院时间=4天组(40例,30%)和住院时间>4天组(59例,54%)时,观察到并发症发生率存在显著差异。根据Clavien-Dindo手术并发症分类,住院时间为4天或更长时间的患者发生了11例3级和11例4级并发症(p<0.0001)。术后输血、深静脉血栓形成、肺栓塞、心房颤动、呼吸困难/肺不张、肠梗阻和急性肾衰竭均显著预测住院时间>4天(p<0.001)。

结论

接受RPN治疗的患者中有15.8%的住院时间为4天或更长。住院时间延长与较高的Charlson指数、肾计量评分(不可改变因素)以及围手术期并发症(可能可改变)独立相关。这些数据可能有助于围手术期咨询和支付方预认证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43fd/6943947/a5382b6a62f3/fig-1.jpg

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