Effect of sizofilan, an immunomodulator, on hepatic microsomal mixed-function oxidase activities in rats.
作者信息
Yomogida S, Koiwai K, Shiba Y, Ishikawa M, Takayanagi Y, Sasaki K
机构信息
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
出版信息
Jpn J Pharmacol. 1989 Aug;50(4):499-502. doi: 10.1254/jjp.50.499.
PMID:2528647
Abstract
Mixed-function oxidase activities of hepatic microsomal preparations from rats were examined after intraperitoneal administration of sizofilan (SPG), an immunomodulator. Repeated doses of SPG (3 mg/kg/12 hr, 4 times) depressed the hepatic cytochrome P-450 content and the activities of aminopyrine N-demethylase and aniline hydroxylase.
摘要
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