Kharseeva G G, Alieva A A
Zh Mikrobiol Epidemiol Immunobiol. 2014 Jul-Aug(4):109-17.
The paper is devoted to the study of surface structures including pili (fimbriae) 67-72p surface protein, DIP 1281 surface protein, lipoarabinomannan CdiLAM and their role in the adhesion and colonization of the mucous membrane of the throat by Corynebacterium diphtheriae. A description is offered for the main stages in the adhesion process of diphtheria causative agent and the ability of its adhesins to stimulate the effect of innate and acquired immunity factors. The paper stresses prospectiveness of the development of vaccines forming immunoprotection of the organism against adhesive activity of C. diphtheriae and also preventing their colonization and reproduction. That would facilitate a solution for the problem of diphtheria carrier state, which cannot be solved using the existing means of preventive vaccination.
本文致力于研究包括菌毛（纤毛）、67 - 72p表面蛋白、DIP 1281表面蛋白、脂阿拉伯甘露聚糖CdiLAM在内的表面结构，以及它们在白喉棒状杆菌粘附和定植于咽喉粘膜中的作用。文中描述了白喉病原体粘附过程的主要阶段及其粘附素刺激先天免疫和获得性免疫因子作用的能力。本文强调了开发疫苗的前景，这种疫苗可形成针对白喉棒状杆菌粘附活性的免疫保护，还能防止其定植和繁殖。这将有助于解决白喉带菌状态的问题，而现有的预防性疫苗接种手段无法解决该问题。
