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全身性尼卡地平作为先前皮瓣失败后对抗血管痉挛的辅助药物。

Systemic nicardipine as an adjunct to combat vasospasm after prior flap failure.

作者信息

Michelotti Brett F, Rajjoub Samer, Johnson T Shane

机构信息

Division of Plastic Surgery, The Pennsylvania State University, College of Medicine, Hershey, Pa.

出版信息

Plast Reconstr Surg Glob Open. 2013 Nov 7;1(7):e54. doi: 10.1097/GOX.0b013e3182aa8747. eCollection 2013 Oct.

DOI:10.1097/GOX.0b013e3182aa8747
PMID:25289249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4174056/
Abstract

Unrecognized or untreated vasospasm in microsurgery can lead to flap hypoperfusion and failure. Numerous strategies have been explored for their efficacy in potentiating vasodilation. We present a case of unrecognized vasospasm leading to flap failure followed by a second free flap reconstruction in which severe vasospasm was treated with systemic nicardipine used as an adjunct to other more commonly employed antispasmodics. Although the literature investigating the use of systemic calcium channel blockade in microsurgery is limited, it should be considered an alternative when addressing arterial vasospasm.

摘要

显微外科手术中未被识别或未得到治疗的血管痉挛可导致皮瓣灌注不足和坏死。人们已经探索了许多策略来增强血管舒张的效果。我们报告一例未被识别的血管痉挛导致皮瓣坏死的病例，随后进行了第二次游离皮瓣重建，术中使用尼卡地平全身给药作为其他常用解痉药物的辅助治疗，成功治疗了严重的血管痉挛。尽管关于全身应用钙通道阻滞剂在显微外科手术中的研究文献有限，但在处理动脉血管痉挛时应考虑将其作为一种替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97b6/4174056/2718f6be8d65/gox-1-e54-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97b6/4174056/5ac77323c242/gox-1-e54-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97b6/4174056/2718f6be8d65/gox-1-e54-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97b6/4174056/5ac77323c242/gox-1-e54-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97b6/4174056/2718f6be8d65/gox-1-e54-g002.jpg

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Salvage of compromised free flaps in trauma cases with combined modalities.创伤病例中联合治疗方式抢救失活游离皮瓣
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J Reconstr Microsurg. 1995 May;11(3):179-83. doi: 10.1055/s-2007-1006528.
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Comparison of vascular effects of ropivacaine and lidocaine on isolated rings of human arteries.罗哌卡因和利多卡因对人离体动脉环血管作用的比较。
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