杂交杂交瘤与双特异性单克隆抗体的产生
Hybrid hybridomas and the production of bi-specific monoclonal antibodies.
作者信息
Milstein C, Cuello A C
机构信息
Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
出版信息
Immunol Today. 1984 Oct;5(10):299-304. doi: 10.1016/0167-5699(84)90155-5.
PMID:25290548
Abstract
Cell fusion techniques can now be used to generate antibodies with two different specificities. Here Cesar Milstein and A. C. Cuello discuss the theoretical basis of the method they have devised and its first applications in histochemistry and immunoassay.
摘要
细胞融合技术现在可用于生成具有两种不同特异性的抗体。在此，塞萨尔·米尔斯坦和A.C. 奎洛讨论了他们所设计方法的理论基础及其在组织化学和免疫测定中的首次应用。
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