Puccinelli F, Pieraccini F, Tomei G P, Gargiulo L
Clin Ter. 1989 Jul 15;130(1):29-35.
Arterial blood pressure was recorded in 15 hypertensive patients with ischemic cerebrovascular disease in the post-acute stage and under treatment with nicardipine, a drug with tropism for the muscular cells of cerebral vessels. Blood pressure was measured at rest and during rehabilitation sessions. Patients were periodically assessed by Doppler examination of the cerebral vessels in order to evaluate the effect of the drug on vascular resistance. A significant reduction of blood pressure was observed without changes in pulse rate and without significant side effects. Hemodynamic parameters showed reduced resistance of cerebral vessels. These findings confirm the need for accurate control of arterial blood pressure during neurologic rehabilitation; they also bear out the efficacy and safety of nicardipine in this clinical situation.
对15例处于急性后期且正在接受尼卡地平治疗的缺血性脑血管疾病高血压患者记录动脉血压。尼卡地平是一种对脑血管肌细胞有亲和性的药物。在静息状态和康复治疗期间测量血压。通过对脑血管进行多普勒检查对患者进行定期评估，以评价药物对血管阻力的影响。观察到血压显著降低，心率无变化，且无明显副作用。血流动力学参数显示脑血管阻力降低。这些发现证实了在神经康复期间精确控制动脉血压的必要性；它们也证明了尼卡地平在这种临床情况下的有效性和安全性。
