Gospodinoff A, Fiore L, Dardano B, Fiore D, Scapato P
Clin Ter. 1989 Jul 31;130(2):109-13.
The authors report the results of an open clinical study of 60 outpatients of whom 20 were suffering from rheumatoid arthritis and 40 from osteoarthritis. The study was aimed at evaluating the efficacy and tolerability of the new indole derivative acemetacin and at a comparison with etodolac. The drug studied was found to be effective and to be tolerated better than indomethacin, particularly the absence of the most unpleasant side-effect of indole compounds, i.e., headache, was noted.
作者报告了一项针对60名门诊患者的开放性临床研究结果，其中20名患有类风湿性关节炎，40名患有骨关节炎。该研究旨在评估新型吲哚衍生物阿西美辛的疗效和耐受性，并与依托度酸进行比较。研究发现，所研究的药物有效，且耐受性优于吲哚美辛，尤其值得注意的是，它没有吲哚类化合物最令人不适的副作用，即头痛。
