Malkovský M, Medawar P B
Clinical Research Centre, Harrow, Middlesex HA1 3UJ, UK.
Immunol Today. 1984 Dec;5(12):340-3. doi: 10.1016/0167-5699(84)90074-4.
There have been recent demonstrations that immunological tolerance can be MHC-restricted. The same antigen, therefore, can be recognized in the context of an appropriate MHC molecule both as an antigen andas a tolerogen. Here Miroslav Malkovský and Peter Medawar propose that the outcome of the encounter is determined by the availability or effectiveness of interleukin 2. If there is a deficit of the hormone, unresponsiveness is promoted in the T cells which recognize the antigen.
