Albasri Abdulkader Mohammed
Department of Pathology, Taibah University, Madinah, Saudi Arabia E-mail :
Asian Pac J Cancer Prev. 2014;15(18):7673-7. doi: 10.7314/apjcp.2014.15.18.7673.
Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Colon cancer risk in IBD increases with longer duration and greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel. This study aimed to characterize the histopathological pattern of benign colorectal diseases among Saudi patients and to highlight age and gender variations of lesions as base line data for future studies to investigate the link between benign / IBD and colorectal cancers in the local population.
The materials consisted of 684 biopsies, reported as benign (excluding malignancies and polyps) at the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia from January 2006 to December 2013. Data collected and entered in MS-Excel and were analyzed using SPSS-20.
Of 684 colorectal tissues reviewed, 408 specimens (59.6%) were from male patients and 276 specimens (40.4%) were from females giving a male: female ratio of 1.5:1. Age of the patients ranged from 4 to 75 years with a mean of 39.6 years. The most frequent histologic diagnosis was a chronic non specific proctocolitis followed by ulcerative colitis, accounting respectively for 52.6% and 31.7% of all cases. These were followed by Crohn's disease 22 (3.2%), ischemic bowel disease 20 (2.9%), diverticular disease 14 (2%), eosinophilic colitis 12 (1.7%) and solitary rectal ulcer 12 (1.7%). A minority of 21 patients (3.1%) were cases of acute nonspecific proctocolitis, schistosomiasis, tuberculosis, volvulus and pseudomembranous colitis.
These data show that although chronic non specific proctocolitis and ulcerative colitis were the dominant diagnoses, Crohn's disease, ischemic bowel disease and diverticular disease also existed to a lesser extent and should be considered in the differential diagnosis of benign colorectal diseases. This study provides a base line data for future studies which would be taken up to investigate the link between benign / IBD and colorectal cancers in the local population.
长期患有炎症性肠病（IBD）的患者患结直肠癌（CRC）的风险增加。IBD患者患结肠癌的风险随着结肠炎病程延长、解剖范围扩大、原发性硬化性胆管炎的存在、CRC家族史以及肠道炎症程度的增加而升高。本研究旨在描述沙特患者良性结直肠疾病的组织病理学模式，并突出病变的年龄和性别差异，作为未来研究当地人群中良性/IBD与结直肠癌之间联系的基线数据。
材料包括2006年1月至2013年12月在沙特阿拉伯麦地那法赫德国王医院病理科报告为良性（不包括恶性肿瘤和息肉）的684份活检标本。收集的数据录入MS-Excel，并使用SPSS-20进行分析。
在684份结直肠组织标本中，408份标本（59.6%）来自男性患者，276份标本（40.4%）来自女性患者，男女比例为1.5:1。患者年龄范围为4至75岁，平均年龄为39.6岁。最常见的组织学诊断是慢性非特异性直肠结肠炎，其次是溃疡性结肠炎，分别占所有病例的52.6%和31.7%。其次是克罗恩病22例（3.2%）、缺血性肠病20例（2.9%）、憩室病14例（2%）、嗜酸性结肠炎12例（1.7%）和孤立性直肠溃疡12例（1.7%）。少数21例患者（3.1%）为急性非特异性直肠结肠炎、血吸虫病、结核病、肠扭转和假膜性结肠炎病例。
这些数据表明，虽然慢性非特异性直肠结肠炎和溃疡性结肠炎是主要诊断，但克罗恩病、缺血性肠病和憩室病也在较小程度上存在，在良性结直肠疾病的鉴别诊断中应予以考虑。本研究为未来研究提供了基线数据，这些研究将致力于调查当地人群中良性/IBD与结直肠癌之间的联系。
