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近期使用高效液相色谱法（HPLC）和液相色谱-质谱联用（LC-MS(/MS)）对第三代头孢菌素进行定量分析的生物分析方法及其在药代动力学研究中的应用。

Recent bioanalytical methods for quantification of third-generation cephalosporins using HPLC and LC-MS(/MS) and their applications in pharmacokinetic studies.

作者信息

Jin Hyo-Eon, Jin Su-Eon, Maeng Han-Joo

机构信息

College of Pharmacy, Seoul National University, Seoul, Republic of Korea.

出版信息

Biomed Chromatogr. 2014 Nov;28(11):1565-87. doi: 10.1002/bmc.3330. Epub 2014 Oct 8.

DOI:10.1002/bmc.3330
PMID:25294385
Abstract

Third-generation cephalosporins are semi-synthetic antibiotics with enhanced activity against Gram-negative organisms. The cephalosporins in biological samples are mostly determined using high-performance liquid chromatography (HPLC) and HPLC-mass spectrometry (LC-MS) or tandem mass spectrometry (LC-MS/MS). In recent years, numerous bioanalytical methods have been developed to improve the sensitivity and specificity of cephalosporin quantification using the powerful LC-MS/MS systems that are common in research laboratories. This review article presents recently developed bioanalytical methods by HPLC or LC-MS(/MS) for 12 third-generation cephalosporins, including five oral third-generation cephalosporins, and further discusses their application in pharmacokinetic studies of animals and humans.

摘要

第三代头孢菌素是对革兰氏阴性菌具有增强活性的半合成抗生素。生物样品中的头孢菌素大多采用高效液相色谱法（HPLC）、HPLC-质谱联用（LC-MS）或串联质谱法（LC-MS/MS）进行测定。近年来，人们开发了许多生物分析方法，以利用研究实验室中常见的强大的LC-MS/MS系统提高头孢菌素定量的灵敏度和特异性。本文综述了最近通过HPLC或LC-MS（/MS）针对12种第三代头孢菌素（包括5种口服第三代头孢菌素）开发的生物分析方法，并进一步讨论了它们在动物和人体药代动力学研究中的应用。

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