自身免疫性疾病孕妇发生静脉血栓栓塞事件的风险：一项基于人群的研究。
Risk of Venous Thromboembolic Events in Pregnant Patients With Autoimmune Diseases: A Population-Based Study.
作者信息
Bleau Nathalie, Patenaude Valerie, Abenhaim Haim A
机构信息
Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec, Canada.
出版信息
Clin Appl Thromb Hemost. 2016 Apr;22(3):285-91. doi: 10.1177/1076029614553023. Epub 2014 Oct 7.
OBJECTIVE
The objective of this study is to evaluate the effect of autoimmune disease on the risk of venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) in pregnant women.
METHODS
Using the Health Care Cost and Utilization Project, Nationwide Inpatient Sample database from 2003 to 2011, the risk of developing DVT, PE, and VTE among pregnant patients with selected autoimmune diseases was estimated using unconditional logistic regression analysis.
RESULTS
Our study cohort consisted of 7 917 453 women of which 43 523 had underlying autoimmune diseases. Risk of VTE was high in pregnant women with systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis, type 1 diabetes mellitus, ulcerative colitis, and Crohn's disease.
CONCLUSION
Most autoimmune diseases considerably increase the risk of VTE. Thromboprophylaxis may be considered in pregnancies with autoimmune disease, particularly those with systemic lupus erythematosus and dermatomyositis.
目的
本研究旨在评估自身免疫性疾病对孕妇发生静脉血栓栓塞症（VTE，包括深静脉血栓形成（DVT）和肺栓塞（PE））风险的影响。
方法
利用2003年至2011年医疗保健成本与利用项目全国住院患者样本数据库，采用无条件逻辑回归分析估计患有特定自身免疫性疾病的孕妇发生DVT、PE和VTE的风险。
结果
我们的研究队列包括7917453名女性，其中43523名患有潜在的自身免疫性疾病。系统性红斑狼疮、皮肌炎、类风湿关节炎、1型糖尿病、溃疡性结肠炎和克罗恩病孕妇的VTE风险较高。
结论
大多数自身免疫性疾病会显著增加VTE风险。对于患有自身免疫性疾病的孕妇，尤其是患有系统性红斑狼疮和皮肌炎的孕妇，可考虑进行血栓预防。
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