Dong Biao, Zhang Jianjian, Wang Gang, Zhai Xiuyu, Fu Yaowen, Zhou Honglan, Wang Yuantao
Department of Urology, First Hospital of Jilin University, Jilin, China;
Department of Hepatic Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Can Urol Assoc J. 2014 Sep;8(9-10):E657-9. doi: 10.5489/cuaj.1854.
A solitary fibrous tumour (SFT) is a rare mesenchymal cell neoplasm that can develop at any site. SFT of the kidney is extremely rare. Recently, we had a case of solitary fibrous tumour involving the left kidney in a 71-year-old female patient. The SFT was incidentally found by imaging modalities at the time of a physical workup. Computed tomography and retrograde pyelography showed a 4 × 3.5 × 4-cm nodular mass in the middle poles of the left kidney adjacent to the renal pelvis. A laparoscopic radical resection of the left kidney was performed. The tumour was well-circumscribed and composed of a mixture of spindle cells; microscopically, we found dense collagenous bands. Immunohistochemical studies showed strong reactions with CD34, bcl-2 and CD99. A nuclear positivity with Ki-67 was observed in less than 1% of cells. The tumour was negative for desmin, SMA and CD117. Histopathological and immunohistochemical studies confirmed the diagnosis of a solitary fibrous tumour.
孤立性纤维瘤（SFT）是一种罕见的间充质细胞瘤，可发生于任何部位。肾孤立性纤维瘤极为罕见。最近，我们遇到一例71岁女性患者的左肾孤立性纤维瘤。该SFT在体检时通过影像学检查偶然发现。计算机断层扫描和逆行肾盂造影显示左肾中极靠近肾盂处有一个4×3.5×4厘米的结节状肿块。对左肾进行了腹腔镜根治性切除术。肿瘤边界清晰，由梭形细胞混合组成；显微镜下，我们发现了致密的胶原带。免疫组织化学研究显示对CD34、bcl-2和CD99有强烈反应。观察到Ki-67核阳性的细胞少于1%。肿瘤对结蛋白、平滑肌肌动蛋白和CD117呈阴性。组织病理学和免疫组织化学研究证实了孤立性纤维瘤的诊断。
