Falk Alexander T, Moncharmont Coralie, Guilbert Matthieu, Guy Jean-Baptiste, Alphonse Gersende, Trone Jane-Chloé, Rivoirard Romain, Gilormini Marion, Toillon Robert-Alain, Rodriguez-Lafrasse Claire, Magné Nicolas
Centre Antoine Lacassagne, Département de radiothérapie, 33, avenue de Valombrose, 06189 Nice cedex, France.
Institut de Cancérologie Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France, Faculté de Médecine Lyon Sud, EMR3738, Laboratoire de Radiobiologie Cellulaire et Moléculaire, 69921 Oullins, France.
Bull Cancer. 2014 Sep;101(9):876-80. doi: 10.1684/bdc.2014.1946.
Glioblastoma multiform is the most common and aggressive brain tumor with a worse prognostic. Ionizing radiation is a cornerstone in the treatment of glioblastome with chemo-radiation association being the actual standard. As a paradoxal effect, it has been suggested that radiotherapy could have a deleterious effect on local recurrence of cancer. In vivo studies have studied the effect of radiotherapy on biological modification and pathogenous effect of cancer cells. It seems that ionizing radiations with photon could activate oncogenic pathways in glioblastoma cell lines. We realized a review of the literature of photon-enhanced effect on invasion and migration of glioblastoma cells by radiotherapy.
多形性胶质母细胞瘤是最常见且侵袭性最强的脑肿瘤，预后较差。电离辐射是胶质母细胞瘤治疗的基石，化疗联合放疗是目前的标准治疗方法。然而，有矛盾的研究结果表明，放疗可能对癌症的局部复发产生有害影响。体内研究已经探讨了放疗对癌细胞生物学改变和致病作用的影响。似乎光子电离辐射可激活胶质母细胞瘤细胞系中的致癌途径。我们对关于放疗对胶质母细胞瘤细胞侵袭和迁移的光子增强效应的文献进行了综述。
