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一种基于瓣环周长的术中替代方法,用于指导预防性三尖瓣环成形术的决策。

An alternative intraoperative method based on annular circumference for the decision-making of prophylactic tricuspid annuloplasty.

作者信息

Zhu Tie-Yuan, Meng Xu, Han Jie, Li Yan, Ma Ning

出版信息

J Heart Valve Dis. 2014 May;23(3):370-6.

Abstract

BACKGROUND AND AIM OF THE STUDY

Tricuspid valve exploration during surgery plays an important role in the decision-making of concomitant tricuspid annuloplasty at the time of left-sided valve surgery. However, at present a good standard to define tricuspid annular dilatation is not available. The study aim was to introduce an alternative method based on annular circumference to judge the extent of annular dilatation, and investigate its predictive ability for the postoperative progression of tricuspid regurgitation (TR).

METHODS

A total of 127 patients with non-significant TR who underwent isolated left-sided valve surgery at the authors' institution between October 2010 and October 2011 were enrolled prospectively in the study. Intraoperative measurements of the tricuspid annular circumference (TAC) were made for each patient and adjusted to the patient's body surface area to give the TAC index (TACI). The primary end-point was defined as the progression of TR by more than two grades, or a final TR grade > or = 3+ at follow up echocardiography.

RESULTS

The mean follow up period was 30.2 months (range: 24-37 months). Three variables were found to be associated with postoperative TR progression, including atrial fibrillation, left atrial diameter, and the intraoperatively measured TACI (p = -0.1 in univariate analysis). However, on multiple regression analysis only the TACI (OR 1.586; 95% CI 1.303-1.929; p < 0.001) was significantly associated with TR progression. Based on the receiver-operator characteristic curve, it was possible to derive an optimal cut-off value (83 mm/m2) to predict the postoperative development of TR with higher sensitivity and specificity.

CONCLUSION

Among a patient population with predominantly rheumatic left-sided valve disease, the tricuspid annular circumference, when assessed with special sizers, proved to be an ideal method to judge if the annulus would dilate, or not, during surgery. A deduced TACI threshold of 83 mm/m2 was recommended as an indication for prophylactic tricuspid repair.

摘要

研究背景与目的

在手术过程中对三尖瓣进行探查,对于在左侧瓣膜手术时决定是否同期进行三尖瓣环成形术具有重要作用。然而,目前尚无一个良好的标准来定义三尖瓣环扩张。本研究的目的是引入一种基于瓣环周长的替代方法来判断瓣环扩张程度,并研究其对三尖瓣反流(TR)术后进展的预测能力。

方法

2010年10月至2011年10月期间,在作者所在机构接受单纯左侧瓣膜手术且TR不严重的127例患者被前瞻性纳入本研究。术中对每位患者的三尖瓣环周长(TAC)进行测量,并根据患者体表面积进行调整,得出三尖瓣环周长指数(TACI)。主要终点定义为随访超声心动图显示TR进展超过两级,或最终TR分级≥3+。

结果

平均随访期为30.2个月(范围:24 - 37个月)。发现三个变量与术后TR进展相关,包括心房颤动、左心房直径以及术中测量的TACI(单因素分析中p = -0.1)。然而,多因素回归分析显示只有TACI(OR 1.586;95%CI 1.303 - 1.929;p < 0.001)与TR进展显著相关。根据受试者工作特征曲线,可以得出一个最佳截断值(83 mm/m²),以更高的敏感性和特异性预测TR的术后发展。

结论

在以风湿性左侧瓣膜病为主的患者群体中,使用特殊测量器评估的三尖瓣环周长被证明是判断手术期间瓣环是否会扩张的理想方法。建议将推导得出的TACI阈值83 mm/m²作为预防性三尖瓣修复的指征。

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