Department of Mechanical Engineering, University of Wisconsin-Milwaukee , 3200 North Cramer Street, Milwaukee, Wisconsin 53211, United States.
ACS Appl Mater Interfaces. 2014;6(21):19235-41. doi: 10.1021/am505275a. Epub 2014 Oct 20.
A field-effect transistor (FET) device-based sensor is developed to specifically detect Pb(2+) ions in an aqueous environment that is notably toxic. Reduced graphene oxide (rGO), as the semiconducting channel material, was utilized in the FET device through a self-assembly method. An l-glutathione reduced was employed as the capture probe for the label-free detection. By monitoring the electrical characteristics of the FET device, the performance of the sensor was measured and investigated. Compared with conventional detection technologies, this sensor enabled real-time detection with a response time of 1-2 s. A lower detection limit for Pb(2+) ions as low as 10 nM was achieved, which is much lower than the maximum contaminant level for Pb(2+) ions in drinking water recommended by the World Health Organization. Furthermore, the rGO FET sensor was able to distinguish Pb(2+) from other metal ions. Without any sample pretreatment, the platform is user-friendly.
一种基于场效应晶体管（FET）器件的传感器被开发出来，用于专门检测水溶液中具有显著毒性的 Pb(2+)离子。还原氧化石墨烯（rGO）作为半导体沟道材料，通过自组装方法被应用于 FET 器件中。l-谷胱甘肽还原物被用作无标记检测的捕获探针。通过监测 FET 器件的电特性，对传感器的性能进行了测量和研究。与传统的检测技术相比，该传感器实现了实时检测，响应时间为 1-2 秒。实现了对 Pb(2+)离子的低检测限，低至 10 nM，远低于世界卫生组织建议的饮用水中 Pb(2+)离子的最大污染物水平。此外，rGO FET 传感器能够区分 Pb(2+)与其他金属离子。该平台无需任何样品预处理，使用方便。
