Indumathi V A, Shikha R, Suryaprakash D R
Department of Microbiology, Mathikere Sampangi Ramaiah Medical College, Bangalore, Karnataka, India.
Indian J Med Microbiol. 2014 Oct-Dec;32(4):443-5. doi: 10.4103/0255-0857.142250.
Corynebacterium pseudodiphtheriticum is a common commensal flora of the upper respiratory tract in humans. Though the pathogenicity of C. pseudodiphtheriticum is not rare, its role as an opportunistic pathogen is mainly limited to the lower respiratory tract, particularly in patients with underlying systemic conditions or immune-compromisation. We hereby present the first case of C. pseudodiphtheriticum causing diphtheria-like illness affecting the upper respiratory tract of a 6-year-old fully immunised otherwise healthy child. In countries with very low incidence of diphtheria, C. pseudodiphtheriticum should be included in differential diagnosis for a child presenting with diphtheria-like illness. Simple, rapid screening tests should be used to differentiate it from C. diphtheriae and hence, to prevent unnecessary concern in community.
假白喉棒状杆菌是人类上呼吸道常见的共生菌群。尽管假白喉棒状杆菌的致病性并不罕见,但其作为机会致病菌的作用主要局限于下呼吸道,尤其是在患有潜在全身性疾病或免疫功能低下的患者中。我们在此报告首例假白喉棒状杆菌引起类似白喉疾病的病例,该疾病影响了一名6岁完全免疫且原本健康儿童的上呼吸道。在白喉发病率极低的国家,对于出现类似白喉疾病的儿童,应将假白喉棒状杆菌纳入鉴别诊断。应使用简单、快速的筛查试验将其与白喉棒状杆菌区分开来,从而避免在社区引起不必要的担忧。