Beard J D, Scott D J, Skidmore R, Baird R N, Horrocks M
Vascular Studies Unit, Bristol Royal Infirmary, UK.
Br J Surg. 1989 Sep;76(9):925-8. doi: 10.1002/bjs.1800760917.
Operative measurements using a newly developed Doppler flowmeter were made on 47 in situ femorodistal bypass grafts performed for critical ischaemia. Graft blood flow, peripheral resistance and impedance were measured before and after the injection of 15 mg papaverine down the graft. The proportion of retrograde blood flow at the distal anastomosis was also measured. The success of a graft at 1 month was defined by patency on duplex ultrasound scanning, a rise in the Doppler ankle pressures and an improvement in the clinical state of the limb. By these criteria the 1-month primary success rate was 35 out of 47 (74 per cent). Graft blood flow was of little value in predicting graft outcome but, combined with segmental pressures, accurately located six of eight technical problems which were successfully corrected. After papaverine, the peripheral resistance of all the successful grafts fell below one peripheral resistance unit (PRU). No single measurement was able to completely distinguish between success and failure, although discriminant analysis of all measurements was able to predict success with a sensitivity of 100 per cent and specificity of 97 per cent. A simpler combination of a peripheral resistance after papaverine less than 1 PRU and a retrograde blood flow less than 33 per cent predicted success, with a sensitivity of 97 per cent and specificity 83 per cent. These criteria have been validated on a further 26 grafts, achieving a sensitivity of 88 per cent and a specificity of 75 per cent. Simple operative measurements, using a newly developed Doppler flowmeter, enable the detection of technical problems and the accurate prediction of the early outcome of femorodistal grafting.
使用一种新开发的多普勒流量计,对47例因严重缺血而进行的原位股腘动脉搭桥移植术进行了术中测量。在通过移植物注射15毫克罂粟碱前后,测量了移植物血流量、外周阻力和阻抗。还测量了远端吻合口处的逆向血流比例。移植物在1个月时的成功定义为经双功超声扫描显示通畅、多普勒踝压升高以及肢体临床状况改善。根据这些标准,47例中有35例(74%)在1个月时获得了初步成功。移植物血流量对预测移植物结果价值不大,但与节段压力相结合,准确地定位了8个技术问题中的6个,这些问题均得到成功纠正。注射罂粟碱后,所有成功移植物的外周阻力均降至1个外周阻力单位(PRU)以下。尽管对所有测量值进行判别分析能够以100%的灵敏度和97%的特异性预测成功,但没有单一测量能够完全区分成功与失败。罂粟碱后外周阻力小于1 PRU且逆向血流小于33%的更简单组合预测成功,灵敏度为97%,特异性为83%。这些标准在另外26例移植物上得到验证,灵敏度为88%,特异性为75%。使用新开发的多普勒流量计进行简单的术中测量,能够检测技术问题并准确预测股腘动脉移植术的早期结果。