SCH 23390对多巴胺D1受体的阻断作用可拮抗喷他佐辛的辨别性刺激效应。

Blockade of dopamine D1 receptors by SCH 23390 antagonizes discriminative stimulus effects of pentazocine.

作者信息

Ukai M, Nakayama S, Hamada T, Kameyama T

机构信息

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.

出版信息

Brain Res. 1989 Sep 4;496(1-2):377-9. doi: 10.1016/0006-8993(89)91092-5.

DOI:10.1016/0006-8993(89)91092-5

PMID:2529950

Abstract

The purpose of this investigation was to test the hypothesis that the discriminative stimulus properties of pentazocine are mediated through an interaction with dopamine receptors. Rats were trained to discriminate s.c. injections of pentazocine (3.0 mg/kg) from vehicle in a two-choice discrete trial avoidance paradigm. SCH 23390 (0.003-0.056 mg/kg), a selective antagonist of dopamine D1 receptors, inhibited the discriminative stimulus effects of pentazocine in a dose-dependent fashion, whilst the selective D2 receptor antagonist sulpiride (20.0-80.0 mg/kg) did not antagonize them. It appears that the dopamine D1 receptors play an important role in the discriminative stimulus effects of pentazocine.

摘要

本研究的目的是检验喷他佐辛的辨别性刺激特性是通过与多巴胺受体相互作用介导的这一假设。在双选离散试验回避范式中，训练大鼠区分皮下注射的喷他佐辛（3.0毫克/千克）和溶媒。多巴胺D1受体的选择性拮抗剂SCH 23390（0.003 - 0.056毫克/千克）以剂量依赖性方式抑制喷他佐辛的辨别性刺激作用，而选择性D2受体拮抗剂舒必利（20.0 - 80.0毫克/千克）则不能拮抗这些作用。看来多巴胺D1受体在喷他佐辛的辨别性刺激作用中起重要作用。