Stanzel Tisha Prabriputaloong, Diaz Jose D, Mather Rookaya, Wong Ira G, Margolis Todd P, Gritz David C
Francis I. Proctor Foundation, University of California San Francisco , San Francisco, CA , USA .
Ophthalmic Epidemiol. 2014 Dec;21(6):370-7. doi: 10.3109/09286586.2014.966848. Epub 2014 Oct 9.
To calculate the incidence and prevalence of herpes simplex virus (HSV) eye disease in a large, well-defined population in Northern California, USA, and to determine the recurrence rate following an initial episode of disease in this cohort.
A retrospective, observational, cohort study using population-based data and medical record review. The patient database of a large, regional health maintenance organization (Northern California Kaiser Permanente) was searched, and the study population consisted of 1,042,351 people over a 1-year study period from 1 July 1998 through 30 June 1999. Only ocular HSV cases with definitive clinical or laboratory confirmed diagnoses were included. Active and inactive cases were included, however only active cases were used in incidence and prevalence calculations. Bilateral disease was counted as one case. Newly diagnosed cases were followed for recurrence from initial presentation through 31 December 2002.
After chart review of 322 possible cases, 71 new cases and 59 previously diagnosed active cases of ocular HSV were confirmed. This resulted in an incidence rate of 6.8 new cases/100,000 person-years (95% confidence interval, CI, 5.3-8.6). Incidence increased with age, and rates were highest in people over 75 years of age (p < 0.001). The recurrence rate in new cases was 18% for the 3-year follow-up time, and was equal to 5% per year (95% CI 3-9%).
The incidence and prevalence of ocular herpes simplex in this study was lower than previously reported. Incidence increased with age, and there were significantly higher rates in the older population.
计算美国北加利福尼亚州一个大规模、明确界定人群中单纯疱疹病毒（HSV）眼病的发病率和患病率，并确定该队列中疾病首次发作后的复发率。
一项回顾性观察队列研究，使用基于人群的数据和病历审查。检索了一个大型区域健康维护组织（北加利福尼亚州凯撒医疗集团）的患者数据库，研究人群包括1998年7月1日至1999年6月30日这1年研究期间的1,042,351人。仅纳入具有明确临床或实验室确诊诊断的眼部HSV病例。纳入了活动期和非活动期病例，但发病率和患病率计算仅使用活动期病例。双侧疾病计为1例。对新诊断的病例从首次就诊至2002年12月31日进行复发随访。
在对322例可能病例进行病历审查后，确诊了71例新病例和59例先前诊断的眼部HSV活动期病例。这导致发病率为6.8例新病例/100,000人年（95%置信区间，CI，5.3 - 8.6）。发病率随年龄增加而升高，75岁以上人群的发病率最高（p < 0.001）。新病例在3年随访期内的复发率为18%，相当于每年5%（95% CI 3 - 9%）。
本研究中眼部单纯疱疹的发病率和患病率低于先前报道。发病率随年龄增加而升高，老年人群中的发病率显著更高。
