Laux B
Hautklinik der Universität Mainz.
Hautarzt. 1989 Sep;40(9):577-81.
In the course of a randomized, comparative, clinical study, 50 patients with acne vulgaris received systemic treatment with a single daily dose of 50 mg doxycycline or two daily doses of 50 mg minocycline. At the completion of the 12-week treatment, cure or improvement of acne was found in 78% of the patients in the doxycycline group compared to 82% in the minocycline group. The rate of unsatisfactory therapeutic results was 22% in the doxycycline group and 18% in the group of patients treated with minocycline. The results showed no significant difference between the clinical efficacy of treating acne vulgaris with doxycycline at a daily dose of 50 mg and 100 mg of minocycline daily, a fact which has already been demonstrated by earlier studies.
在一项随机、对照临床研究过程中，50例寻常痤疮患者接受了系统治疗，其中一组每日单次服用50mg强力霉素，另一组每日分两次服用50mg美满霉素。在为期12周的治疗结束时，强力霉素组78%的患者痤疮得到治愈或改善，而美满霉素组这一比例为82%。强力霉素组治疗效果不理想的比例为22%，美满霉素治疗组为18%。结果显示，每日服用50mg强力霉素与每日服用100mg美满霉素治疗寻常痤疮的临床疗效之间无显著差异，这一事实已被早期研究所证实。
