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一种用于葡萄酒色斑光动力治疗的带激光的医用操纵器系统。

A medical manipulator system with lasers in photodynamic therapy of port wine stains.

作者信息

Wang Xingtao, Tian Chunlai, Duan Xingguang, Gu Ying, Huang Naiyan

机构信息

State Nuclear Power Technology Research & Development Centre, Floor 7, Building A, South Area of Future Science and Technology Park, Beiqijia Town, Changping District, State Nuclear Power Research Institute, Beijng 102209, China.

Intelligent Robotics Institute, Beijing Institute of Technology, 5 Nandajie, Zhongguancun, Haidian, Beijing 100081, China.

出版信息

Biomed Res Int. 2014;2014:384646. doi: 10.1155/2014/384646. Epub 2014 Aug 14.

DOI:10.1155/2014/384646
PMID:25302297
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4181501/
Abstract

Port wine stains (PWS) are a congenital malformation and dilation of the superficial dermal capillary. Photodynamic therapy (PDT) with lasers is an effective treatment of PWS with good results. However, because the laser density is uneven and nonuniform, the treatment is carried out manually by a doctor thus providing little accuracy. Additionally, since the treatment of a single lesion can take between 30 and 60 minutes, the doctor can become fatigued after only a few applications. To assist the medical staff with this treatment method, a medical manipulator system (MMS) was built to operate the lasers. The manipulator holds the laser fiber and, using a combination of active and passive joints, the fiber can be operated automatically. In addition to the control input from the doctor over a human-computer interface, information from a binocular vision system is used to guide and supervise the operation. Clinical results are compared in nonparametric values between treatments with and without the use of the MMS. The MMS, which can significantly reduce the workload of doctors and improve the uniformity of laser irradiation, was safely and helpfully applied in PDT treatment of PWS with good therapeutic results.

摘要

葡萄酒色斑(PWS)是一种先天性的真皮浅层毛细血管畸形和扩张。激光光动力疗法(PDT)是治疗PWS的一种有效方法,效果良好。然而,由于激光密度不均匀,治疗由医生手动进行,因此准确性较低。此外,由于单个病变的治疗可能需要30至60分钟,医生在进行几次治疗后就会感到疲劳。为了辅助医护人员采用这种治疗方法,构建了一个医疗机械手系统(MMS)来操作激光。机械手握住激光光纤,通过主动关节和被动关节的组合,可以自动操作光纤。除了医生通过人机界面进行控制输入外,双目视觉系统的信息还用于指导和监督操作。对使用和不使用MMS进行治疗的非参数值的临床结果进行比较。MMS能够显著减轻医生的工作量并提高激光照射的均匀性,已安全有效地应用于PWS的PDT治疗,取得了良好的治疗效果。

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Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review.前瞻性葡萄酒色斑研究中使用的临床结局测量和评分系统:系统评价。

本文引用的文献

1
Photodynamic therapy in China: Over 25 years of unique clinical experience Part two-Clinical experience.中国的光动力疗法:25 年以上独特的临床经验 第二部分——临床经验。
Photodiagnosis Photodyn Ther. 2006 Jun;3(2):71-84. doi: 10.1016/j.pdpdt.2006.03.001. Epub 2006 Apr 18.
2
Photodynamic therapy in China: Over 25 years of unique clinical experience Part One-History and domestic photosensitizers.中国的光动力疗法:超过 25 年的独特临床经验 第一部分-历史与国产光敏剂。
Photodiagnosis Photodyn Ther. 2006 Mar;3(1):3-10. doi: 10.1016/S1572-1000(06)00009-3. Epub 2006 Mar 6.
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Photodynamic therapy of port wine stains-a report of 238 cases.
PLoS One. 2020 Jul 2;15(7):e0235657. doi: 10.1371/journal.pone.0235657. eCollection 2020.
光动力疗法治疗葡萄酒色斑 238 例报告。
Photodiagnosis Photodyn Ther. 2007 Mar;4(1):53-9. doi: 10.1016/j.pdpdt.2007.01.001. Epub 2007 Feb 12.
4
Research and development of photodynamic therapy photosensitizers in China.中国光动力疗法光敏剂的研究与开发。
Photodiagnosis Photodyn Ther. 2007 Mar;4(1):13-25. doi: 10.1016/j.pdpdt.2006.09.003. Epub 2006 Nov 13.
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Robotic technologies and rehabilitation: new tools for stroke patients' therapy.机器人技术与康复: stroke 患者治疗的新工具。
Biomed Res Int. 2013;2013:153872. doi: 10.1155/2013/153872. Epub 2013 Nov 20.
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Photodynamic therapy in treatment of port wine stain birthmarks--recent progress.光动力疗法治疗葡萄酒色斑出生胎记——最新进展。
Photodiagnosis Photodyn Ther. 2009 Sep-Dec;6(3-4):189-94. doi: 10.1016/j.pdpdt.2009.08.001. Epub 2009 Sep 10.
7
Comparison of photodynamic therapy and pulsed dye laser in patients with port wine stain birthmarks: a retrospective analysis.鲜红斑痣患者中光动力疗法与脉冲染料激光的比较:一项回顾性分析。
Photodiagnosis Photodyn Ther. 2008 Mar;5(1):50-7. doi: 10.1016/j.pdpdt.2007.12.001. Epub 2008 Feb 19.
8
[Clinical study of 1949 cases of port wine stains treated with vascular photodynamic therapy (Gu's PDT)].1949例鲜红斑痣血管光动力治疗(顾氏光动力疗法)的临床研究
Ann Dermatol Venereol. 2007 Mar;134(3 Pt 1):241-4. doi: 10.1016/s0151-9638(07)91816-5.