Stoop A E, Hameleers D M, v Run P E, Biewenga J, van der Baan S
Department of Otorhinolaryngology/Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.
J Allergy Clin Immunol. 1989 Nov;84(5 Pt 1):734-41. doi: 10.1016/0091-6749(89)90302-3.
Immunohistochemical stainings were performed on biopsy specimens of the middle and inferior turbinates of the nasal mucosa of 14 patients with nasal polyps and 16 healthy subjects. Significantly more CD8+ (T suppressor/cytotoxic) cells than CD4+ (T helper/inducer) cells were found in the lamina propria of the middle and inferior turbinates of patients with nasal polyps and in the inferior turbinate of healthy subjects. The middle and inferior turbinates of healthy subjects contained significantly more CD4+ cells than the middle and inferior turbinates of patients with nasal polyps. CD19+ B cells were hardly detected in the patients and healthy subjects. More HLA-DR+ cells were found in the middle than in the inferior turbinate, especially in the patients. Varying but small numbers of eosinophils, neutrophils, mast cells, and plasma cells were found in patients and healthy subjects. The possible role of CD4+, CD8+, and HLA-DR+ cells in the nasal mucosa is discussed with regard to the pathogenesis of nasal polyps.
对14例鼻息肉患者和16名健康受试者鼻黏膜中鼻甲和下鼻甲的活检标本进行免疫组织化学染色。在鼻息肉患者的中鼻甲和下鼻甲固有层以及健康受试者的下鼻甲中，发现CD8 +（T抑制/细胞毒性）细胞明显多于CD4 +（T辅助/诱导）细胞。健康受试者的中鼻甲和下鼻甲所含CD4 +细胞比鼻息肉患者的中鼻甲和下鼻甲明显更多。在患者和健康受试者中几乎检测不到CD19 + B细胞。中鼻甲中发现的HLA-DR +细胞比下鼻甲更多，尤其是在患者中。在患者和健康受试者中发现了数量不等但少量的嗜酸性粒细胞、中性粒细胞、肥大细胞和浆细胞。就鼻息肉的发病机制讨论了CD4 +、CD8 +和HLA-DR +细胞在鼻黏膜中的可能作用。
