Buszczak Michael, Signer Robert A J, Morrison Sean J
Department of Molecular Biology, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Howard Hughes Medical Institute, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Cell. 2014 Oct 9;159(2):242-51. doi: 10.1016/j.cell.2014.09.016.
Although sometimes considered a "house-keeping" function, multiple aspects of protein synthesis are regulated differently among somatic cells, including stem cells, and can be modulated in a cell-type-specific manner. These differences are required to establish and maintain differences in cell identity, cell function, tissue homeostasis, and tumor suppression.
尽管蛋白质合成的多个方面有时被视为一种“管家”功能,但在包括干细胞在内的体细胞中,其调控方式存在差异,并且可以以细胞类型特异性的方式进行调节。这些差异对于建立和维持细胞身份、细胞功能、组织稳态及肿瘤抑制方面的差异是必需的。