Mellema Jos J, Doornberg Job N, Guitton Thierry G, Ring David
Orthopaedic Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
University of Amsterdam Orthopaedic Residency Program (PGY 4), Academic Medical Center, Amsterdam, The Netherlands.
Injury. 2014 Dec;45(12):2035-9. doi: 10.1016/j.injury.2014.09.014. Epub 2014 Sep 28.
It is our impression that many biomechanical studies invest substantial resources studying the obvious: that more and larger metal is stronger. The purpose of this study is to evaluate if a subset of biomechanical studies comparing fixation constructs just document common sense.
Using a web-based survey, 274 orthopaedic surgeons and 81 medical students predicted the results of 11 biomechanical studies comparing fracture fixation constructs (selected based on the authors' sense that the answer was obvious prior to performing the study). Sensitivity, specificity, and accuracy were calculated according to standard formulas. The agreement among the observers was calculated by using a multirater kappa, described by Siegel and Castellan.
The accuracy of predicting outcomes was 80% or greater for 10 of 11 studies. Accuracy was not influenced by level of experience (i.e., time in practice and medical students vs. surgeons). There were substantial differences in accuracy between observers from different regions. The overall categorical rating of inter-observer reliability according to Landis and Koch was moderate (κ=0.55; standard error (SE)=0.01).
The results of a subset of biomechanical studies comparing fracture fixation constructs can be predicted prior to doing the study. As these studies are time and resource intensive, one criterion for proceeding with a biomechanical study should be that the answer is not simply a matter of common sense.
我们的印象是,许多生物力学研究投入了大量资源去研究显而易见的事情:更多、更大的金属更强。本研究的目的是评估一部分比较固定结构的生物力学研究是否只是在记录常识。
通过基于网络的调查,274名骨科医生和81名医学生预测了11项比较骨折固定结构的生物力学研究的结果(这些研究是根据作者在进行研究之前认为答案显而易见而挑选的)。根据标准公式计算敏感性、特异性和准确性。观察者之间的一致性通过使用Siegel和Castellan描述的多评分者kappa来计算。
11项研究中有10项预测结果的准确性达到80%或更高。准确性不受经验水平(即从业时间以及医学生与外科医生)的影响。不同地区的观察者在准确性上存在显著差异。根据Landis和Koch的标准,观察者间可靠性的总体分类评级为中等(κ=0.55;标准误差(SE)=0.01)。
一部分比较骨折固定结构的生物力学研究结果在进行研究之前就能被预测。由于这些研究耗费时间和资源,开展生物力学研究的一个标准应该是答案并非仅仅是常识问题。