Stoianov B G, Fedorov S M, Selisskiĭ G D, Agakishiev D D, Alchangian L V
Vestn Dermatol Venerol. 1989(7):29-34.
Allergenic and photosensitizing effects of organophosphorus pesticides (OPP) have been detected, as well as their destructive effect on the skin cell ultrastructure, on the body metabolism and enzymic systems, and the inhibitory effect on cholinesterase activity. Pesticide-induced changes in polyunsaturated fatty acids (PUFA) are significant in the mechanism of dermatoses development. The complex of treatment-and-prophylaxis measures includes regular dermatologic check-ups and limitation of the number of subjects handling OPP. Subjects in whom premorbid shifts have been detected, should be followed up. The therapy and prevention of the dermatoses developing as a result of exposure to pesticides may be effectively carried out with antioxidants, amino acids, vitamins, etc.; diets with the optimal PUFA-tocopherol ratio are advisable. Overalls with multiple protective physicochemical characteristics, filtering respirators and such are recommended.
已检测到有机磷农药（OPP）的致敏和光敏作用，以及它们对皮肤细胞超微结构、机体代谢和酶系统的破坏作用，以及对胆碱酯酶活性的抑制作用。农药引起的多不饱和脂肪酸（PUFA）变化在皮肤病发生机制中具有重要意义。治疗和预防措施包括定期皮肤科检查以及限制接触有机磷农药的人员数量。已检测到病前变化的受试者应进行随访。使用抗氧化剂、氨基酸、维生素等可以有效治疗和预防因接触农药而引发的皮肤病；建议采用具有最佳PUFA-生育酚比例的饮食。推荐使用具有多种防护物理化学特性的工作服、过滤式呼吸器等。
