Trofimova I B, Tupitsyn N N, Sholokhova E N, Kadagidze Z G, Baryshnikov A B
Vestn Dermatol Venerol. 1989(8):9-14.
Comprehensive analysis of skin infiltrate cells, carried out in malignant lymphomas of the skin, has included examinations with the use of monoclonal antibodies (MCA). Basing on the clinical, histologic, and immunologic findings, mycosis fungoides has been diagnosed in 9 patients and T-cellular lymphoblastic lymphosarcoma consisting of T-suppressors in 1. The findings evidence that (1) mycosis fungoides is a tumor consisting of OKT4 cells in the majority of cases; (2) mature T-cell markers are sometimes lost in the course of mycosis fungoides, this being parallelled by the emergence of antigens characteristic of earlier differentiation stages, e. g. corticothymocytic ones; (3) immunologic heterogeneity is a characteristic feature of malignant lymphomas of the skin; this may be explained by both: the tumor progress of the clone and the therapeutic pathomorphosis; (4) use of MCA to a wide spectrum of leukocytic differentiation antigens permits an accurate estimation of the nature of the tumor cells and of the cellular relationships; this helps understand the pathogenesis of malignant lymphomas of the skin and develop new treatment modalities.
对皮肤恶性淋巴瘤中的皮肤浸润细胞进行的综合分析，包括使用单克隆抗体（MCA）进行检测。根据临床、组织学和免疫学检查结果，9例患者被诊断为蕈样肉芽肿，1例为主要由T抑制细胞组成的T细胞淋巴母细胞性淋巴瘤。这些结果证明：（1）在大多数情况下，蕈样肉芽肿是一种由OKT4细胞组成的肿瘤；（2）在蕈样肉芽肿病程中，成熟T细胞标志物有时会丢失，与此同时会出现早期分化阶段特征性的抗原，如皮质胸腺细胞抗原；（3）免疫异质性是皮肤恶性淋巴瘤的一个特征；这可能由以下两方面原因解释：克隆的肿瘤进展和治疗性病理形态改变；（4）将MCA用于广泛的白细胞分化抗原，能够准确评估肿瘤细胞的性质和细胞间关系；这有助于理解皮肤恶性淋巴瘤的发病机制并开发新的治疗方法。
