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机械通气的儿科重症监护病房患儿的肺泡复张手法

Alveolar recruitment maneuver in mechanic ventilation pediatric intensive care unit children.

作者信息

Neves Valéria Cabral, Koliski Adriana, Giraldi Dinarte José

机构信息

Unidade de Terapia Intensiva Pediátrica, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.

Departamento de Pediatria, Universidade Federal do Paraná.

出版信息

Rev Bras Ter Intensiva. 2009 Dec;21(4):453-60.

Abstract

Recent changes were introduced in acute hypoxemic respiratory failure children ventilation methods. There are evidences that less aggressive ventilation strategies can improve severe pulmonary injury survival. Experimental trials evidenced a relationship between inappropriate ventilatory measures and delayed acute pulmonary injury improvement, or even worsening. From this, a protective ventilatory measure arises in combination with alveolar recruitment maneuver. This association is believed in clinical practice to determine importantly reduced morbidity and mortality as well as reduced mechanic ventilation-induced injuries. It is indicated for acute lung injury patients, generally from pneumonia or sepsis, with severe hypoxemia. Its main contraindications are homodynamic instability, pneumothorax and intracranial hypertension. Experimental trials showed beneficial maneuver effects on both oxygenation and alveolar collapse. Adult studies showed improved pulmonary function with hypoxemia reversion. In children, the maneuver lead to significant inspired oxygen fraction and alveolar collapse reductions, less oxygen dependency, improved pulmonary complacency, and reduced bronchopulmonary dysplasia. However, studies in children are limited. Additional investigation is warranted on this matter, and its clinical application evidence. A literature review was conducted based on textbooks and MEDLINE, Pubmed, Cochrane library, SciELO, and Ovid databases, from 1998 to 2009, both in Portuguese and English. Publications on alveolar recruitment maneuver both in adults and children, review articles, experimental and clinical trials were included using the key words: protective ventilatory strategy, alveolar recruitment maneuver, pediatrics and mechanic ventilation.

摘要

近期,针对急性低氧性呼吸衰竭儿童的通气方法有了新变化。有证据表明,采用不那么激进的通气策略可提高严重肺损伤患者的生存率。实验性试验证明,不适当的通气措施与急性肺损伤改善延迟甚至病情恶化之间存在关联。由此,一种与肺泡复张手法相结合的保护性通气措施应运而生。在临床实践中,人们认为这种联合措施能显著降低发病率和死亡率,以及减少机械通气引起的损伤。它适用于患有严重低氧血症、通常由肺炎或败血症引起的急性肺损伤患者。其主要禁忌症为血流动力学不稳定、气胸和颅内高压。实验性试验表明,该手法对氧合和肺泡萎陷均有有益作用。成人研究显示,随着低氧血症的逆转,肺功能得到改善。在儿童中,该手法可显著降低吸入氧分数和肺泡萎陷程度,减少对氧气的依赖,改善肺顺应性,并降低支气管肺发育不良的发生率。然而,关于儿童的研究有限。对此问题及其临床应用证据有必要进行进一步调查。我们基于教科书以及1998年至2009年期间葡萄牙语和英语的MEDLINE、Pubmed、Cochrane图书馆、SciELO和Ovid数据库进行了文献综述。纳入了关于成人和儿童肺泡复张手法的出版物、综述文章、实验性和临床试验,关键词为:保护性通气策略、肺泡复张手法、儿科学和机械通气。

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