朝觐者中A、C、W和Y血清群脑膜炎球菌血清杀菌抗体谱
Meningococcal serogroup A, C, W, and Y serum bactericidal antibody profiles in Hajj pilgrims.
作者信息
Memish Ziad A, Yezli Saber, Almasri Malak, Assiri Abdullah, Turkestani Abdulhafeez, Findlow Helen, Bai Xilian, Borrow Ray
机构信息
Global Centre for Mass Gatherings Medicine (GCMGM), Ministry of Health, Riyadh, Kingdom of Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.
Global Centre for Mass Gatherings Medicine (GCMGM), Ministry of Health, Riyadh, Kingdom of Saudi Arabia.
出版信息
Int J Infect Dis. 2014 Nov;28:171-5. doi: 10.1016/j.ijid.2014.09.005. Epub 2014 Oct 12.
BACKGROUND
The religious seasons of Hajj and Umra in the Kingdom of Saudi Arabia (KSA) have historically been associated with epidemics of meningococcal disease. Due to the effective preventive measures taken in recent years, including vaccination, no meningococcal outbreaks have been reported during Hajj or were Hajj-associated. However, little is known about the immunological profile of pilgrims. The aim of this study was to assess the immunological profile of pilgrims on arrival in KSA against the four meningococcal serogroups, A, C, W, and Y, contained within the quadrivalent vaccine.
METHODS
Following consent, socio-demographic factors and health-related information was collected from pilgrims arriving at King Abdul Aziz International Airport and a blood sample taken. Antibodies were quantified by serum bactericidal antibody assay using baby rabbit complement (rSBA) against the four meningococcal serogroups, A, C, W, and Y.
RESULTS
Serum samples were collected from 796 pilgrims; rSBA results were obtained for all four serogroups for 741 of these samples. A total of 48 (6.5%) Hajjis had previously attended Hajj, ranging from 1 to 14 times (median 2 times); 98.2% had received meningococcal quadrivalent vaccine in the last 3 years. Of the 13 who had not, all originated from Bangladesh, with four reporting no previous meningococcal vaccination and nine reporting having received the vaccination more than 3 years ago. For serogroup A, only one pilgrim from Indonesia had an rSBA titre <8. For serogroups C, W, and Y, the percentages of pilgrims with rSBA titres <8 were 9.9%, 17.4%, and 9.4%, respectively. Of note was the high prevalence of non-complement-mediated lysis in pilgrims originating from Nigeria (28/47; 59.6%) and Afghanistan (21/47; 44.7%), but not the other countries. This may be a reflection of the type and pattern of antibiotic usage among these communities.
CONCLUSION
The vast majority of pilgrims are vaccinated and protected against meningococcal serogroups A, C, W, and Y.
背景
在沙特阿拉伯王国，朝觐和副朝的宗教活动在历史上一直与脑膜炎球菌病的流行有关。由于近年来采取了有效的预防措施，包括接种疫苗，在朝觐期间或与朝觐相关的活动中未报告有脑膜炎球菌病暴发。然而，对于朝圣者的免疫状况知之甚少。本研究的目的是评估抵达沙特阿拉伯的朝圣者针对四价疫苗中包含的A、C、W和Y这四种脑膜炎球菌血清群的免疫状况。
方法
在获得同意后，收集抵达阿卜杜勒·阿齐兹国王国际机场的朝圣者的社会人口统计学因素和健康相关信息，并采集血样。使用兔血清补体通过血清杀菌抗体试验（rSBA）对针对A、C、W和Y这四种脑膜炎球菌血清群的抗体进行定量。
结果
收集了796名朝圣者的血清样本；其中741份样本获得了针对所有四种血清群的rSBA结果。共有48名（6.5%）朝觐者曾参加过朝觐，次数从1次到14次不等（中位数为2次）；98.2%的人在过去3年内接种过脑膜炎球菌四价疫苗。在未接种的13人中，所有人都来自孟加拉国，其中4人报告此前未接种过脑膜炎球菌疫苗，9人报告接种时间超过3年。对于A血清群，只有一名来自印度尼西亚的朝圣者的rSBA滴度<8。对于C、W和Y血清群，rSBA滴度<8的朝圣者百分比分别为9.9%、17.4%和9.4%。值得注意的是，来自尼日利亚（28/47；59.6%）和阿富汗（21/47；44.7%）的朝圣者中，非补体介导的溶解发生率较高，而其他国家的朝圣者中则没有。这可能反映了这些群体中抗生素使用的类型和模式。
结论
绝大多数朝圣者接种了疫苗，对A、C、W和Y脑膜炎球菌血清群具有免疫力。
Zotero 插件