Autoimmun Rev. 2015 Jan;14(1):49-56. doi: 10.1016/j.autrev.2014.10.002.
Vitiligo is a hypomelanotic autoimmune skin disease arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses against melanocytes. Regulatory T cells (Tregs) are crucial to the development of self-tolerance and so are major foci in the study of autoimmune pathogenesis of vitiligo. This review will summarise recent findings concerning the role of Tregs in the pathogenesis of vitiligo. In addition, as antigen-specific Tregs are a potential route for the reinstatement of immune tolerance, new strategies that expand or induce de novo generation of Tregs and which are currently being investigated as therapies for other autoimmune diseases, will be discussed. These approaches will highlight the opportunities for Treg cell-based therapeutics in vitiligo.
白癜风是一种由免疫自身耐受打破引起的色素减退性自身免疫性皮肤病，导致针对黑素细胞的异常免疫反应。调节性 T 细胞（Tregs）对自身耐受的发展至关重要，因此是白癜风自身免疫发病机制研究的重点。本综述将总结 Tregs 在白癜风发病机制中的作用的最新发现。此外，由于抗原特异性 Tregs 是恢复免疫耐受的潜在途径，因此将讨论目前正在作为其他自身免疫性疾病的治疗方法进行研究的扩展或诱导 Treg 新生的新策略。这些方法将突出 Treg 细胞治疗在白癜风中的应用机会。
