Bigham-Sadegh Amin, Karimi Iraj, Shadkhast Mohamad, Mahdavi Mohamad-Hosein
Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran,
J Orthop Traumatol. 2015 Jun;16(2):141-9. doi: 10.1007/s10195-014-0323-x. Epub 2014 Oct 12.
Synthetic hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP) and their composite are promising biomaterials, specifically in the orthopedic and dental fields, as their chemical composition is similar to that of bone. Due to the need for safer bone graft applications, these bone graft substitutes are gradually gaining increased acceptability. To stimulate the process of bone healing, several methods have been used previously, including ultrasound, electrical stimulation, exposure to electromagnetic fields, bone grafts, interporous hydroxyapatite (as a bone graft substitute) and bone growth factors. The following study was designed to evaluate the effects of the concurrent usage of hydroxyapatite with demineralized calf fetal growth plate (DCFGP) on the bone healing process.
Fifteen female New Zealand white rabbits were used in this study. A mid-radius bone defect was created and in the first group (n = 5) was filled with hydroxyapatite, in the second group (n = 5) with hydroxyapatite and DCFGP, and finally in the third group (n = 5) with DCFGP alone. Radiological and histopathological evaluations were performed blindly and the results scored and analyzed statistically.
There was a significant difference for bone formation and remodeling at the 8th post-operative week radiographic assessment (P < 0.05), when the hydroxyapatite-DCFGP group was superior to other groups. On the contrary, macroscopical and histopathological evaluation did not revealed significant differences between the three groups
Given the contrasting results of the radiographic assessment and the macro-/microscopic analysis of the healing response, further studies are needed before considering DCFGP-HA as a feasible alternative to HA alone, especially considering the potential hazards and costs of animal-derived biomaterials.
Not applicable.
合成羟基磷灰石（HA）、β-磷酸三钙（β-TCP）及其复合材料是很有前景的生物材料，尤其在骨科和牙科领域，因为它们的化学成分与骨骼相似。由于对更安全的骨移植应用的需求，这些骨移植替代物逐渐获得了更高的认可度。为了刺激骨愈合过程，此前已经使用了多种方法，包括超声、电刺激、暴露于电磁场、骨移植、多孔羟基磷灰石（作为骨移植替代物）和骨生长因子。以下研究旨在评估羟基磷灰石与脱矿化小牛胎儿生长板（DCFGP）同时使用对骨愈合过程的影响。
本研究使用了15只雌性新西兰白兔。制造了桡骨中段骨缺损，第一组（n = 5）填充羟基磷灰石，第二组（n = 5）填充羟基磷灰石和DCFGP，最后第三组（n = 5）仅填充DCFGP。对放射学和组织病理学评估进行盲法操作，并对结果进行评分和统计学分析。
术后第8周进行放射学评估时，骨形成和重塑存在显著差异（P < 0.05），此时羟基磷灰石-DCFGP组优于其他组。相反，宏观和组织病理学评估未显示三组之间存在显著差异。
鉴于放射学评估结果与愈合反应的宏观/微观分析结果存在差异，在将DCFGP-HA视为单独使用HA的可行替代方案之前，需要进一步研究，尤其是考虑到动物源性生物材料的潜在危害和成本。
不适用。
