Bigham A S, Dehghani S N, Shafiei Z, Nezhad S Torabi
Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
Cell Tissue Bank. 2009 Feb;10(1):33-41. doi: 10.1007/s10561-008-9107-y. Epub 2008 Sep 23.
The following study was designed to evaluate xenogenic bovine demineralized bone matrix (DBM) and new xenograft (Bovine fetal growth plate) effects on bone healing process. Twenty male White New Zealand rabbits were used in this study. In group I (n = 10) the defect was filled by xenogenic DBM and in group II (n = 10) the defect was filled by a segment of bovine fetal growth plate and was fixed by cercelage wire. Radiological, histopathological, and biomechanical evaluations were performed blindly and results scored and analyzed statistically. Statistical tests did not support significant differences between two groups radiographically (P > 0.05). There was a significant difference for union at the 28th postoperative radiologically (P < 0.05). Xenograft was superior to DBM group at the 28th postoperative day for radiological union (P < 0.03). Histopathological and biomechanical evaluation revealed no significant differences between two groups. In conclusion, the results of this study indicate that satisfactory healing occurred in rabbit radius defect filled with xenogenic bovine DBM and xenogenic bovine fetal growth plate. Complications were not identified and healing was faster in two grafting groups.
以下研究旨在评估异种牛脱矿骨基质（DBM）和新型异种移植物（牛胎儿生长板）对骨愈合过程的影响。本研究使用了20只雄性新西兰白兔。在第一组（n = 10）中，缺损用异种DBM填充；在第二组（n = 10）中，缺损用一段牛胎儿生长板填充并用环扎钢丝固定。对放射学、组织病理学和生物力学评估进行盲法操作，并对结果进行评分和统计学分析。统计学检验不支持两组在放射学上存在显著差异（P > 0.05）。术后第28天在放射学上骨愈合存在显著差异（P < 0.05）。术后第28天，在放射学骨愈合方面，异种移植物组优于DBM组（P < 0.03）。组织病理学和生物力学评估显示两组之间无显著差异。总之，本研究结果表明，用异种牛DBM和异种牛胎儿生长板填充的兔桡骨缺损实现了满意的愈合。未发现并发症，且两个移植组的愈合速度更快。
