Allen J W, Kaiser P J, Montenegro A
Heart, Inc., Hospital of the Good Samaritan, Los Angeles, California 90017.
Am J Cardiol. 1989 Nov 15;64(18):1157-61. doi: 10.1016/0002-9149(89)90870-9.
Echocardiographic studies of left ventricular (LV) hypertrophy indicate clinical benefits of antihypertensive therapy. Therefore, M-mode and Doppler techniques were used to assess changes in LV hypertrophy after 10, 30 and 50 weeks of atenolol therapy (50 or 100 mg once daily) in 19 patients with essential hypertension. After 50 weeks of atenolol treatment, the most notable changes were: for M-mode parameters, increases (p less than 0.05) in diastolic LV internal dimension, radius to thickness ratio and stroke volume, and decreases (p less than 0.01) in total wall thickness and heart rate; for Doppler parameters, increases (p less than 0.01) in slope and peripheral resistance, and decreases (p less than 0.01) in heart rate, stroke volume and cardiac output. The decreased total wall thickness and increased radius to thickness ratio suggest a trend toward regression of LV hypertrophy. These findings, along with improvements in blood pressure, pulse and exercise stress tests, indicate potential benefits of atenolol in managing patients with essential hypertension and LV hypertrophy.
超声心动图对左心室（LV）肥厚的研究表明了抗高血压治疗的临床益处。因此，采用M型和多普勒技术评估了19例原发性高血压患者在接受阿替洛尔治疗（50或100mg，每日一次）10周、30周和50周后左心室肥厚的变化。阿替洛尔治疗50周后，最显著的变化为：对于M型参数，舒张期左心室内径、半径与厚度比及每搏输出量增加（p<0.05），总壁厚及心率降低（p<0.01）；对于多普勒参数，斜率及外周阻力增加（p<0.01），心率、每搏输出量及心输出量降低（p<0.01）。总壁厚降低及半径与厚度比增加提示左心室肥厚有消退趋势。这些发现，连同血压、脉搏及运动应激试验的改善，表明阿替洛尔在治疗原发性高血压和左心室肥厚患者方面具有潜在益处。
