Widman Erik, Caidahl Kenneth, Heyde Brecht, D'hooge Jan, Larsson Matilda
Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Ultrasound Med Biol. 2015 Jan;41(1):77-88. doi: 10.1016/j.ultrasmedbio.2014.06.013. Epub 2014 Oct 11.
Our objective was to validate a previously developed speckle tracking (ST) algorithm to assess strain in common carotid artery plaques. Radial and longitudinal strain was measured in common carotid artery gel phantoms with a plaque-mimicking inclusion using an in-house ST algorithm and sonomicrometry. Moreover, plaque strain by ST for seven patients (77 ± 6 y) with carotid atherosclerosis was compared with a quantitative visual assessment by two experienced physicians. In vitro, good correlation existed between ST and sonomicrometry peak strains, both radially (r = 0.96, p < 0.001) and longitudinally (r = 0.75, p < 0.01). In vivo, greater pulse pressure-adjusted radial and longitudinal strains were found in echolucent plaques than in echogenic plaques. This illustrates the feasibility of ultrasound ST strain estimation in plaques and the possibility of characterizing plaques using ST strain in vivo.
我们的目标是验证一种先前开发的斑点追踪（ST）算法，以评估颈总动脉斑块中的应变。使用内部ST算法和超声测微法，在含有模拟斑块内含物的颈总动脉凝胶模型中测量径向和纵向应变。此外，还将7例（77±6岁）颈动脉粥样硬化患者的ST斑块应变与两位经验丰富的医生进行的定量视觉评估进行了比较。在体外，ST与超声测微法峰值应变之间存在良好的相关性，无论是径向（r = 0.96，p < 0.001）还是纵向（r = 0.75，p < 0.01）。在体内，发现无回声斑块中的脉搏压力调整后的径向和纵向应变大于回声斑块。这说明了超声ST应变估计在斑块中的可行性，以及在体内使用ST应变对斑块进行特征化的可能性。
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