Nichols Kristen R, Knoderer Chad A, Johnston Bethanne, Wilson Amy C
Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana ; Department of Pharmacy, Riley Hospital for Children, Indiana University Health, Indianapolis, Indiana.
Department of Pharmacy Practice, College of Pharmacy and Health Sciences, Butler University, Indianapolis, Indiana.
J Pediatr Pharmacol Ther. 2014 Jul;19(3):202-5. doi: 10.5863/1551-6776-19.3.202.
A 2-year-old male with chronic kidney disease with secondary hyperparathyroidism developed hypercalcemia while receiving calcitriol, without achieving a serum parathyroid hormone concentration within the goal range. Cinacalcet 15 mg (1.2 mg/kg), crushed and administered via gastrostomy tube, was added to the patient's therapy. This therapy was effective in achieving targeted laboratory parameters in our patient despite instructions in the prescribing information that cinacalcet should always be taken whole.
一名患有慢性肾脏病伴继发性甲状旁腺功能亢进的2岁男性在接受骨化三醇治疗期间出现高钙血症，且血清甲状旁腺激素浓度未达到目标范围。遂在患者治疗中加用西那卡塞15毫克（1.2毫克/千克），碾碎后经胃造瘘管给药。尽管处方信息中说明西那卡塞应整片服用，但该治疗仍有效使我们的患者达到了目标实验室指标。
