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[注射吸毒:重症监护病房入院后的生存情况及死亡时的法医毒理学报告]

[Injecting drug abuse: survival after intensive care admission and forensic toxicology reports at death].

作者信息

Sigvaldason Kristinn, Ingvarsson Thoroddur, Thordardottir Svava, Kristinsson Jakob, Karason Sigurbergur

出版信息

Laeknabladid. 2014 Oct;100(10):515-9. doi: 10.17992/lbl.2014.10.561.

DOI:10.17992/lbl.2014.10.561
PMID:25310040
Abstract

INTRODUCTION

Injecting drug abuse is a worldwide problem with serious consequences for the individual and for society. The purpose of this study was to gather information on the most serious complications of injecting drug use from two perspectives, intensive care admissions and forensic toxicology reports.

MATERIAL AND METHODS

Firstly, intensive care admissions related to injecting drug abuse during a five year period were reviewed for demographics, complications and 5 year survival. Secondly, information from forensic toxicology reports regarding deaths amongst known injecting drug abusers were gathered for the same period.

RESULTS

A total of 57 patients with a history of active injecting drug use were admitted to intensive care or approximately 1% of admissions, most often for overdose (52%) or life threatening infections (39%). Median age was 26, males were 66%. The most common substances used were prescription drugs. Hospital mortality was 16% and five year survival 65%. Average time from hospital discharge to death was 916±858 days. During the study period 38 deaths of individuals with a history of injecting drugs were identified by forensic toxicology reports or 4.1/10(5) population/year (age 15-59). Cause of death was most often overdose (53%), usually from prescription opiates but multiple drug use was common.

DISCUSSION

The life expectancy of injecting drug abusers after intensive care admission is substantially decreased, with 35% death rate within five years. A widespread use of prescription drugs is of concern. Injecting drug abuse seems to be a similar health problem in magnitude in Iceland as in other Scandinavian countries.

摘要

引言

注射吸毒是一个全球性问题,对个人和社会都会造成严重后果。本研究的目的是从重症监护入院情况和法医毒理学报告这两个角度收集有关注射吸毒最严重并发症的信息。

材料与方法

首先,回顾了五年期间与注射吸毒相关的重症监护入院患者的人口统计学资料、并发症情况及五年生存率。其次,收集了同一时期法医毒理学报告中有关已知注射吸毒者死亡情况的信息。

结果

共有57名有注射吸毒史的患者入住重症监护病房,约占入院患者的1%,最常见的原因是药物过量(52%)或危及生命的感染(39%)。中位年龄为26岁,男性占66%。最常使用的物质是处方药。医院死亡率为16%,五年生存率为65%。出院至死亡的平均时间为916±858天。在研究期间,法医毒理学报告确定有38名有注射吸毒史的人死亡,即4.1/10(5)人口/年(年龄15 - 59岁)。死亡原因最常见的是药物过量(53%),通常是处方阿片类药物,但多药滥用也很常见。

讨论

注射吸毒者在重症监护入院后的预期寿命大幅缩短,五年内死亡率为35%。处方药的广泛使用令人担忧。冰岛的注射吸毒问题在严重程度上似乎与其他斯堪的纳维亚国家类似。

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