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妊娠期高血压的药物治疗

Pharmacological management of hypertension in pregnancy.

作者信息

Easterling Thomas R

机构信息

Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195.

出版信息

Semin Perinatol. 2014 Dec;38(8):487-95. doi: 10.1053/j.semperi.2014.08.016. Epub 2014 Oct 11.

DOI:10.1053/j.semperi.2014.08.016
PMID:25311173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4272602/
Abstract

Hypertension in pregnancy remains a significant public health problem. Pharmacological management of blood pressure in pregnancy is impacted by changes in maternal drug disposition and by the pharmacodynamic effects of specific agents. This article will review the impact of pregnancy on pathways of drug elimination and the associated clinical implications, the pharmacodynamic effects of specific drugs and classes of drugs in pregnancy, and the data to date on the impact of antihypertensive therapy on mothers and their fetuses.

摘要

妊娠期高血压仍然是一个重大的公共卫生问题。孕期血压的药物治疗受到母体药物处置变化以及特定药物的药效学效应的影响。本文将综述妊娠对药物消除途径的影响及相关临床意义、孕期特定药物和药物类别的药效学效应，以及迄今为止关于降压治疗对母亲及其胎儿影响的数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab64/4272602/eb660be9ac7f/nihms634992f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab64/4272602/eb660be9ac7f/nihms634992f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab64/4272602/eb660be9ac7f/nihms634992f1.jpg

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1
Antihypertensive drug therapy for mild to moderate hypertension during pregnancy.妊娠期轻度至中度高血压的抗高血压药物治疗。
Cochrane Database Syst Rev. 2014 Feb 6(2):CD002252. doi: 10.1002/14651858.CD002252.pub3.
2
Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy.妊娠期高血压。美国妇产科医师学会妊娠期高血压特别工作组报告
Obstet Gynecol. 2013 Nov;122(5):1122-1131. doi: 10.1097/01.AOG.0000437382.03963.88.
3
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.
硫酸镁联合硝苯地平治疗妊娠期高血压综合征时血清炎症因子的变化及临床意义
Exp Ther Med. 2020 Aug;20(2):1796-1802. doi: 10.3892/etm.2020.8863. Epub 2020 Jun 10.
4
Brazilian Cardiology Society Statement for Management of Pregnancy and Family Planning in Women with Heart Disease - 2020.巴西心脏病学会关于心脏病女性妊娠管理与计划生育的声明 - 2020年
Arq Bras Cardiol. 2020 Jun 1;114(5):849-942. doi: 10.36660/abc.20200406.
5
Effect of N-Acetyltransferase 2 Genotype on the Pharmacokinetics of Hydralazine During Pregnancy.乙酰转移酶 2 基因型对妊娠期肼屈嗪药代动力学的影响。
J Clin Pharmacol. 2019 Dec;59(12):1678-1689. doi: 10.1002/jcph.1477. Epub 2019 Jun 30.
6
Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature.Adrb2 通过发育调控胰岛血管来控制血糖稳态。
Elife. 2018 Oct 10;7:e39689. doi: 10.7554/eLife.39689.
7
Maternal antihypertensive medication use and selected birth defects in the National Birth Defects Prevention Study.母亲使用降压药物与美国国家出生缺陷预防研究中选定的出生缺陷。
Birth Defects Res. 2018 Nov 15;110(19):1433-1442. doi: 10.1002/bdr2.1372. Epub 2018 Sep 10.
8
Correlation between the expression of inflammatory cytokines IL-6, TNF-α and hs-CRP and unfavorable fetal outcomes in patients with pregnancy-induced hypertension.妊娠高血压患者炎症细胞因子IL-6、TNF-α及hs-CRP表达与不良妊娠结局的相关性
Exp Ther Med. 2018 Sep;16(3):1982-1986. doi: 10.3892/etm.2018.6393. Epub 2018 Jul 2.
9
Regulators of G protein signaling in cardiovascular function during pregnancy.妊娠期心血管功能中 G 蛋白信号转导的调节因子。
Physiol Genomics. 2018 Aug 1;50(8):590-604. doi: 10.1152/physiolgenomics.00037.2018. Epub 2018 Apr 27.
10
Uncovering the Pharmacological Mechanism of Astragalus Salvia Compound on Pregnancy-Induced Hypertension Syndrome by a Network Pharmacology Approach.基于网络药理学方法揭示黄芪丹参复方治疗妊娠高血压综合征的药理机制。
Sci Rep. 2017 Dec 4;7(1):16849. doi: 10.1038/s41598-017-17139-x.
细胞色素 P450 酶在药物代谢中的作用：基因表达调控、酶活性及遗传变异的影响。
Pharmacol Ther. 2013 Apr;138(1):103-41. doi: 10.1016/j.pharmthera.2012.12.007. Epub 2013 Jan 16.
4
Hypertension and antihypertensive drugs in pregnancy and perinatal outcomes.妊娠和围生期结局中的高血压和降压药物。
Am J Obstet Gynecol. 2013 Apr;208(4):301.e1-6. doi: 10.1016/j.ajog.2012.11.011. Epub 2012 Nov 15.
5
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Am J Perinatol. 2013 Apr;30(4):275-81. doi: 10.1055/s-0032-1323590. Epub 2012 Aug 8.
6
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BMJ Open. 2012 Jul 19;2(4). doi: 10.1136/bmjopen-2012-001185. Print 2012.
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Eur J Clin Pharmacol. 2011 Jan;67(1):55-61. doi: 10.1007/s00228-010-0896-0. Epub 2010 Sep 17.
8
Pharmacodynamics of clonidine therapy in pregnancy: a heterogeneous maternal response impacts fetal growth.妊娠期可乐定治疗的药效学：母体的异质性反应影响胎儿生长。
Am J Hypertens. 2010 Nov;23(11):1234-40. doi: 10.1038/ajh.2010.159. Epub 2010 Aug 19.
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Drug Metab Dispos. 2010 Sep;38(9):1393-6. doi: 10.1124/dmd.110.033878. Epub 2010 Jun 22.
10
Preventing maternal death.预防孕产妇死亡。
Sentinel Event Alert. 2010 Jan 26(44):1-4.