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代谢综合征与手术因素与减重手术肺部不良事件及纵向死亡率的相关性。

Association of metabolic syndrome and surgical factors with pulmonary adverse events, and longitudinal mortality in bariatric surgery.

机构信息

Department of Anesthesiology, Tufts University School of Medicine, Tufts Medical Center, Box 298, 800 Washington Street, Boston, MA 02111, USA

Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

出版信息

Br J Anaesth. 2015 Jan;114(1):83-90. doi: 10.1093/bja/aeu362. Epub 2014 Oct 13.

Abstract

BACKGROUND

Postoperative pulmonary complications (PPC) in bariatric surgery have not been well studied. Additionally, many bariatric patients suffer from the metabolic syndrome (MetS), contributing to surgical risk. We examined the incidence of PPC and MetS in a large national bariatric database. Furthermore, we analysed the relationships between morbidity, mortality, PPC, MetS, and several other comorbidities and also surgical factors.

METHODS

The Bariatric Outcomes Longitudinal Database (BOLD™) is a registry that includes up to 365 day outcomes. We analysed data between January 2008 and October 2010. The PPC tracked included pneumonia, atelectasis, pleural effusion, pneumothorax, adult respiratory distress syndrome, and respiratory failure. A composite pulmonary adverse event (CPAE) included the occurrence of any of these. MetS was defined as the combination of hypertension, dyslipidaemia, and diabetes mellitus. The association of MetS and additional comorbibities, procedural data, and patient characteristics with CPAEs was examined with appropriate statistical tests.

RESULTS

A total of 158 405 patients had a low incidence of PPC (0.91%) and a low mortality (0.6%) after bariatric surgery. MetS was prevalent in 12.7%, and was a significant risk factor for CPAE and mortality. Age, BMI, ASA physical status classification, surgical duration, procedure type, MetS (P<0.001), and additional comorbidities were significantly associated with CPAEs.

CONCLUSIONS

The incidence of PPC was low after bariatric surgery. Increasing age, BMI, ASA status, MetS, obstructive sleep apnoea, asthma, congestive heart failure, surgical duration, and procedure type were independently significantly associated with PPC. Pulmonary complications and MetS were significantly associated with increased postoperative mortality.

摘要

背景

减重手术后的肺部并发症(PPC)尚未得到充分研究。此外,许多肥胖症患者患有代谢综合征(MetS),这增加了手术风险。我们在一个大型国家减重数据库中检查了 PPC 和 MetS 的发生率。此外,我们分析了发病率、死亡率、PPC、MetS 以及其他几种合并症和手术因素之间的关系。

方法

减重结果纵向数据库(BOLD™)是一个包含多达 365 天结果的登记处。我们分析了 2008 年 1 月至 2010 年 10 月的数据。跟踪的 PPC 包括肺炎、肺不张、胸腔积液、气胸、成人呼吸窘迫综合征和呼吸衰竭。任何这些疾病的发生都属于复合肺部不良事件(CPAE)。MetS 定义为高血压、血脂异常和糖尿病的组合。使用适当的统计检验检查 MetS 以及其他合并症、手术数据和患者特征与 CPAE 的关联。

结果

共有 158405 例患者在接受减重手术后 PPC 的发生率较低(0.91%),死亡率也较低(0.6%)。MetS 的患病率为 12.7%,是 CPAE 和死亡率的重要危险因素。年龄、BMI、ASA 身体状况分类、手术时间、手术类型、MetS(P<0.001)和其他合并症与 CPAE 显著相关。

结论

减重手术后 PPC 的发生率较低。年龄、BMI、ASA 状态、MetS、阻塞性睡眠呼吸暂停、哮喘、充血性心力衰竭、手术时间和手术类型的增加与 PPC 独立显著相关。肺部并发症和 MetS 与术后死亡率增加显著相关。

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