Neuroimmunology: Disease mechanisms in narcolepsy remain elusive.

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作者信息

Julkunen Ilkka, Partinen Markku

机构信息

Department of Virology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland.

Helsinki Sleep Clinic, VitalMed Research Centre, Sitratori 3, 00420 Helsinki, Finland.

出版信息

Nat Rev Neurol. 2014 Nov;10(11):616-7. doi: 10.1038/nrneurol.2014.191. Epub 2014 Oct 14.

DOI:10.1038/nrneurol.2014.191

PMID:25311588

Abstract

摘要

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Neuroimmunology: Disease mechanisms in narcolepsy remain elusive.

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本文引用的文献

Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns.发作性睡病患者体内的抗体可使大鼠脑中不同细胞群染色，并影响睡眠模式。

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3735-44. doi: 10.1073/pnas.1412189111. Epub 2014 Aug 18.

Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy".研究论文撤稿：“发作性睡病中针对下丘脑泌素/食欲素的CD4⁺ T细胞自身免疫及对2009年甲型H1N1流感一个表位的交叉反应性”

Sci Transl Med. 2014 Jul 30;6(247):247rt1. doi: 10.1126/scitranslmed.3009995.

Cataplexy--clinical aspects, pathophysiology and management strategy.猝倒症——临床特征、病理生理学及管理策略

Nat Rev Neurol. 2014 Jul;10(7):386-95. doi: 10.1038/nrneurol.2014.97. Epub 2014 Jun 3.

Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination.发作性睡病作为一种自身免疫性疾病：H1N1 感染和疫苗接种的作用。

Lancet Neurol. 2014 Jun;13(6):600-13. doi: 10.1016/S1474-4422(14)70075-4.

Pandemic influenza A H1N1 vaccines and narcolepsy: vaccine safety surveillance in action.甲型 H1N1 大流行流感疫苗与发作性睡病：疫苗安全监测发挥作用。

Lancet Infect Dis. 2014 Mar;14(3):227-38. doi: 10.1016/S1473-3099(13)70238-X. Epub 2013 Dec 19.

Passive transfer of narcolepsy: anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice.嗜睡症的被动转移：抗 TRIB2 自身抗体阳性患者 IgG 导致小鼠下丘脑食欲素神经元丢失和睡眠发作。

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Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland.芬兰 2009 年 H1N1 大流行疫苗接种运动后儿童嗜睡症发病率和临床表现增加。

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