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Knockout of the BK β2 subunit reveals the importance of accessorizing your channel.

作者信息

Brenner Robert

机构信息

Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78230

出版信息

J Gen Physiol. 2014 Nov;144(5):351-6. doi: 10.1085/jgp.201411291. Epub 2014 Oct 13.

DOI:10.1085/jgp.201411291
PMID:25311634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4210423/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4210423/ee0a80d4635d/JGP_201411291_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4210423/ba6627d19caa/JGP_201411291_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4210423/ee0a80d4635d/JGP_201411291_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4210423/ba6627d19caa/JGP_201411291_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2933/4210423/ee0a80d4635d/JGP_201411291_Fig2.jpg

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本文引用的文献

1
Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.敲除BK β2亚基可消除小鼠肾上腺嗜铬细胞中BK电流的失活，并导致慢波爆发活动。
J Gen Physiol. 2014 Oct;144(4):275-95. doi: 10.1085/jgp.201411253.
2
Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo.缝隙连接信号传递是活体肾上腺神经内分泌刺激-分泌偶联的应激调节组成部分。
Nat Commun. 2013;4:2938. doi: 10.1038/ncomms3938.
3
Modulation of BK channel voltage gating by different auxiliary β subunits.
不同辅助 β 亚基对 BK 通道电压门控的调节。
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18991-6. doi: 10.1073/pnas.1216953109. Epub 2012 Oct 29.
4
BK potassium channel modulation by leucine-rich repeat-containing proteins.富含亮氨酸重复蛋白对 BK 钾通道的调节。
Proc Natl Acad Sci U S A. 2012 May 15;109(20):7917-22. doi: 10.1073/pnas.1205435109. Epub 2012 Apr 30.
5
Shaping of action potentials by type I and type II large-conductance Ca²+-activated K+ channels.I 型和 II 型大电导钙激活钾通道对动作电位的塑形作用。
Neuroscience. 2011 Sep 29;192:205-18. doi: 10.1016/j.neuroscience.2011.06.028. Epub 2011 Jul 1.
6
Sparse but highly efficient Kv3 outpace BKCa channels in action potential repolarization at hippocampal mossy fiber boutons.稀疏但高效的 Kv3 钾通道在海马苔藓纤维末梢动作电位复极化中超过 BKCa 通道。
J Neurosci. 2011 Jun 1;31(22):8001-12. doi: 10.1523/JNEUROSCI.0972-11.2011.
7
LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium.LRRC26 辅助蛋白允许 BK 通道在静息电压下无需钙离子激活。
Nature. 2010 Jul 22;466(7305):513-6. doi: 10.1038/nature09162. Epub 2010 Jul 7.
8
Differential regulation of action potentials by inactivating and noninactivating BK channels in rat adrenal chromaffin cells.大鼠肾上腺嗜铬细胞中失活型和非失活型大电导钙激活钾通道对动作电位的差异调节
Biophys J. 2009 Oct 7;97(7):1832-42. doi: 10.1016/j.bpj.2009.06.042.
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BK channels modulate pre- and postsynaptic signaling at reciprocal synapses in retina.BK通道调节视网膜中相互突触处的突触前和突触后信号传导。
Nat Neurosci. 2009 May;12(5):585-92. doi: 10.1038/nn.2302. Epub 2009 Apr 12.
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Anticonvulsant effects of the BK-channel antagonist paxilline.BK通道拮抗剂青霉素的抗惊厥作用。
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