支气管肺发育不良相关肺动脉高压新生儿的血浆不对称二甲基精氨酸水平升高。

Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension.

作者信息

Trittmann Jennifer K, Peterson Eric, Rogers Lynette K, Chen Bernadette, Backes Carl H, Klebanoff Mark A, Nelin Leif D

机构信息

The Research Institute at Nationwide Children's Hospital, Columbus, OH; Pulmonary Hypertension Group, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH; Department of Pediatrics, The Ohio State University, Columbus, OH.

Department of Pediatrics, The Ohio State University, Columbus, OH.

出版信息

J Pediatr. 2015 Feb;166(2):230-3. doi: 10.1016/j.jpeds.2014.09.004. Epub 2014 Oct 11.

DOI:10.1016/j.jpeds.2014.09.004

PMID:25311706

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4308509/

Abstract

OBJECTIVE

To test the hypothesis that levels of the endogenous inhibitor of nitric oxide production, asymmetric dimethylarginine (ADMA), would be greater in preterm infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) than in infants with BPD alone.

STUDY DESIGN

A case-control study of 23 patients with both BPD and PH (cases) and 95 patients with BPD but no evidence of PH (controls). Levels of ADMA were compared between cases and controls by t test.

RESULTS

Patients with both BPD and PH had greater plasma levels of ADMA than patients with BPD alone (P = .04). In samples drawn before 28 days of life, greater levels of ADMA were again found in cases compared with controls (P = .02). The plasma arginine-to-ADMA ratio was lower in cases than in controls (P = .03), suggesting a greater likelihood of inhibition of nitric oxide production in patients with both BPD and PH than in patients with BPD alone.

CONCLUSION

In this neonatal BPD cohort, ADMA levels are increased in patients with BPD who develop PH. We speculate that ADMA may be both a biomarker and a potential therapeutic target for preterm infants with BPD-associated PH.

摘要

目的

检验如下假设，即与仅患支气管肺发育不良（BPD）的婴儿相比，患有与BPD相关的肺动脉高压（PH）的早产儿体内一氧化氮生成的内源性抑制剂非对称二甲基精氨酸（ADMA）水平更高。

研究设计

一项病例对照研究，纳入23例同时患有BPD和PH的患者（病例组）以及95例患有BPD但无PH证据的患者（对照组）。通过t检验比较病例组和对照组的ADMA水平。

结果

同时患有BPD和PH的患者血浆ADMA水平高于仅患BPD的患者（P = 0.04）。在出生28天前采集的样本中，病例组的ADMA水平再次高于对照组（P = 0.02）。病例组的血浆精氨酸与ADMA比值低于对照组（P = 0.03），这表明与仅患BPD的患者相比，同时患有BPD和PH的患者抑制一氧化氮生成的可能性更大。