Tang Kewen, Wen Ping, Zhang Panliang, Huang Yan
Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Hunan, China.
Chirality. 2015 Jan;27(1):75-81. doi: 10.1002/chir.22392. Epub 2014 Oct 14.
The enantioselective liquid-liquid extraction of 4-nitro-D,L-phenylalanine (D,L-Nphy) using PdCl2 {(s)-BINAP} as extractant in dichloroethane was studied experimentally in a countercurrent cascade of 10 centrifugal contactor separators (CCSs) at 5°C, involving flow ratio, extractant concentration, and Cl(-) concentration. The steady-state enantiomeric excess (ee) in both stream exits was 90.86% at a 93.29% yield. The predicted value was modeled using an equilibrium stage approach. The correlation between model and experiment was satisfactory. The model was applied to optimize the production of both enantiomers in >97% ee and >99% ee. 14 stages and 16 stages are required for 97% ee and 99% ee for both enantiomers, respectively.
在10个离心接触器分离器（CCS）的逆流级联装置中，于5℃下，以PdCl2{(s)-BINAP}为萃取剂，在二氯乙烷中对4-硝基-D,L-苯丙氨酸（D,L-Nphy）进行对映选择性液液萃取的实验研究，涉及流量比、萃取剂浓度和Cl(-)浓度。在产率为93.29%时，两股物流出口处的稳态对映体过量（ee）为90.86%。使用平衡级方法对预测值进行建模。模型与实验之间的相关性令人满意。该模型用于优化生产ee>97%和ee>99%的两种对映体。两种对映体ee达到97%和99%分别需要14级和16级。
